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Observational Study
. 2022 Feb 1;41(2):206-210.
doi: 10.1097/ICO.0000000000002901.

Impact of Acanthamoeba Keratitis on the Vision-Related Quality of Life of Contact Lens Wearers

Nicole A Carnt  1   2 , Ryan E K Man  3   4 , Eva K Fenwick  3   4 , Ecosse L Lamoureux  3   4 , Lisa J Keay  1
Affiliations
Observational Study

Impact of Acanthamoeba Keratitis on the Vision-Related Quality of Life of Contact Lens Wearers

Nicole A Carnt et al. Cornea. .

Abstract

Purpose: The aim of this study was to determine the impact of Acanthamoeba keratitis (AK) caused by contact lens (CL) use on vision-related quality of life (VRQOL) and the sociodemographic factors and disease outcome associated with VRQOL.

Methods: Sixty-one CL-associated AK cases and 59 asymptomatic CL wearers (mean age ±SD 39.4 ± 16.5 vs. 45.5 ± 15.2 yrs, P = 0.04) were recruited from Moorfields Eye Hospital and Institute for Optometry, London. AK cases were surveyed during active disease and were stratified into "poor" and "good" outcomes based on clinical features. VRQOL was measured using Rasch-transformed scores from the Emotional, Mobility, and Reading domains of the 32-item Impact of Visual Impairment questionnaire. AK cases were compared with controls and "poor" outcomes compared with "good" with multivariable linear regression. Multivariable linear regression models were also used to identify the sociodemographic factors and disease outcome associated with VRQOL.

Results: AK was associated with significant and substantial reductions in all 3 evaluated domains of VRQOL (Reading -59.6%, Mobility -59.8%, and Emotional -66.2%) compared with controls, independent of sociodemographic factors. Patients with AK who experienced poor outcomes, those who were of British White race (compared with all other races) and female, had lower VRQOL scores across all domains. Patients with AK with lower incomes scored worse on Reading and Mobility domains, whereas those with lower education had poorer Emotional scores.

Conclusions: AK has a considerable detrimental impact on VRQOL. Clinicians should consider the importance of referring patients with AK for rehabilitative support and counseling as part of active disease management.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

    1. Dart JK, Saw VP, Kilvington S. Acanthamoeba keratitis: diagnosis and treatment update 2009. Am J Ophthalmol. 2009;148:487–499.e2.
    1. Carnt N, Robaei D, Minassian DC, et al. Acanthamoeba keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications. Br J Ophthalmol. 2018;102:1431–1435.
    1. Bonini S, di Zazzo A, Varacalli G, et al. Acanthamoeba keratitis: perspectives for patients. Curr Eye Res. 2021;46:771–776.
    1. Basch E. Patient-reported outcomes–harnessing patients' voices to improve clinical care. N Engl J Med. 2017;376:105–108.
    1. Lamoureux EL, Pallant JF, Pesudovs K, et al. The impact of vision impairment questionnaire: an assessment of its domain structure using confirmatory factor analysis and rasch analysis. Invest Ophthalmol Vis Sci. 2007;48:1001–1006.

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