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Review
. 2022 Feb 1;41(2):243-248.
doi: 10.1097/ICO.0000000000002694.

Honeycomb Epithelial Edema Associated With Rho Kinase Inhibition: A Case Series and Review of the Literature

Lance J Lyons  1 , Kristi Y Wu, Keith H Baratz, Arthur J Sit
Affiliations
Review

Honeycomb Epithelial Edema Associated With Rho Kinase Inhibition: A Case Series and Review of the Literature

Lance J Lyons et al. Cornea. .

Abstract

The Rho kinase inhibitor netarsudil is a recently approved therapeutic option for the management of increased intraocular pressure in the United States. Although phase 3 clinical trials noted corneal changes related to the medication-namely, nonvisually-significant corneal verticillata-descriptions of a unique form of cystic epithelial edema began to surface as netarsudil (and its sister drug ripasudil, approved in Japan) gained widespread use. This series adds 3 new cases and reviews the current literature on this unique side effect.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

References

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