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Comment
. 2022 Mar;38(3):193-194.
doi: 10.1016/j.pt.2021.12.009. Epub 2022 Jan 14.

Rosettes: a shield for Plasmodium falciparum against artemisinins?

Stephen J Rogerson  1
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Comment

Rosettes: a shield for Plasmodium falciparum against artemisinins?

Stephen J Rogerson. Trends Parasitol. 2022 Mar.

Abstract

Relative resistance of Plasmodium falciparum parasites to artesunate (AS) has been ascribed to mutations in the Kelch 13 gene. Lee et al. describe another potential contributor to resistance: the induction of increased rosetting by trophozoite-infected erythrocytes following short exposures to AS. Dissecting this phenomenon may lead to new insights into AS resistance.

Keywords: artesunate; drug resistance; malaria; rosetting.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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