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Case Reports
. 2022 Jan 17;15(1):e245513.
doi: 10.1136/bcr-2021-245513.

Peripheral dentinogenic ghost cell tumour

Ivan Cabo  1 , André Saura  2 , Ana Rita Cardoso  3 , José Azenha Cardoso  3
Affiliations
Case Reports

Peripheral dentinogenic ghost cell tumour

Ivan Cabo et al. BMJ Case Rep. .

Abstract

The dentinogenic ghost cell tumour (DGCT) is a rare benign neoplasm, which histologically presents itself as an aberrant keratinisation of the epithelium, ghost cells and dentinoid material. Depending on its location there are two different types of DGCT, central or peripheral, with different clinical characteristics. By 2019, there were only 57 cases of DGCT published: 39 of the central type and 18 of the peripheral type.In this clinical case, the authors describe the case of a 78-year-old man with a painless and slow growing mandibular lump. The diagnosis of peripheral DGCT was made by incisional biopsy and the treatment consisted of radical excision with upper marginal mandibulectomy.The aim of the article is to report a clinical case of a rare pathology and, consequently, to help diagnose and better understand its biological behaviour.

Keywords: dentistry and oral medicine; oral and maxillofacial surgery; pathology.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Initial intraoral clinical examination.
Figure 2
Figure 2
Initial orthopantomography (yellow arrow indicates area with soft tissue density; red arrow points to radiotransparent region with radiopaque areas).
Figure 3
Figure 3
Surgical site after excision of the lesion.
Figure 4
Figure 4
Neoplasm after excision.
Figure 5
Figure 5
(A) Histological image compatible with DGCT (He 5 x); (B) odontogenic epithelium with dentinoid material (*) and ghost cells (black arrow) (He 20 x); (C) odontogenic epithelium with ameloblastoma-like characteristics infiltrating the peripheral connective tissue, with dentinoid material (*) and ghost cells (black arrow) (He 20 x); (D) high power view of dentinoid material (*), ghost cells (black arrow) and foci of calcification (yellow arrow) (He 80 x).
Figure 6
Figure 6
Orthopantomography 10 months after surgery.
Figure 7
Figure 7
Intraoral clinical examination 10 months after surgery.
See this image and copyright information in PMC

References

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