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Clinical Trial
. 1978 Apr;62(4):563-5.

Phase II trial of 5-fluorouracil, adriamycin, and mitomycin C in advanced colorectal cancer

D G Haller, P V Woolley, J S Macdonald, L F Smith Jr, P S Schein
  • PMID: 350394
Clinical Trial

Phase II trial of 5-fluorouracil, adriamycin, and mitomycin C in advanced colorectal cancer

D G Haller et al. Cancer Treat Rep. 1978 Apr.

Abstract

Thirty-five patients with advanced measurable colorectal cancer were treated with a combination of 5-fluorouracil (5-FU), adriamycin, and mitomycin C (FAM). Objective regression of tumor was observed in six patients (17%); seven patients (20%) demonstrated stabilization of disease. The FAM regimen was generally well tolerated with toxic effects limited to bone marrow depression and mild-to-moderate nausea and vomiting. FAM combination chemotherapy did not significantly improve survival in responding patients, nor was it more effective than 5-FU alone in achieving objective regression of disease.

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