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Published Erratum
. 2022 Jan 17;12(1):1115.
doi: 10.1038/s41598-022-04977-7.

Author Correction: Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia

Tadaaki Inano  1 , Marito Araki  2   3   4 , Soji Morishita  3   4 , Misa Imai  3 , Yoshihiko Kihara  3   5 , Maho Okuda  3   4   6 , Yinjie Yang  4 , Masafumi Ito  7 , Satoshi Osaga  8 , Hiroyuki Mano  9   10 , Yoko Edahiro  1   3   4 , Tomonori Ochiai  1   3   4 , Kyohei Misawa  1 , Yasutaka Fukuda  1 , Jun Ando  1   2 , Norio Komatsu  11   12   13
Affiliations
Published Erratum

Author Correction: Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia

Tadaaki Inano et al. Sci Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Comparison of clinical parameters between the TN-ET patients and mutated ET patients. (A) Frequencies of driver mutations in the ET patients in our cohort. (B) A diagram presenting the mutation profiles of the TN-ET patients. NC-JAK2/MPL: noncanonical JAK2 and MPL mutation. The WBC count (C), Hb value (D), platelet count (E), and LDH level (F) for the patients classified based on driver mutation status are shown. Gray highlight shows normal range. * < 0.05, ** < 0.01, *** < 0.001, ns: not significant.
Figure 4
Figure 4
Polyclonal hematopoiesis in the TN-ET patients harboring comparable serum levels of cytokines for megakaryopoiesis. (A) Typical profiles of capillary electrophoresis of HpaII-digested gDNA from granulocytes (n = 10) or MNCs (n = 5) and CD3-positive cells. Two HpaII-resistant peaks representing maternal and paternal alleles in polyclonal hematopoiesis. One of these alleles becomes HpaII-sensitive in granulocytes, representing clonal hematopoiesis (arrow). (B) A pie chart presenting the frequencies of clonal and polyclonal hematopoiesis judged by the HUMARA assay in TN-ET. Four of 15 patients who exhibited ambiguous patterns in the HUMARA assay (A) were excluded from the analysis. Comparison of TPO (C) and IL-6 (D) concentrations in the serum among the patients with TN-ET, patients with ET harboring driver mutations, and healthy controls.
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