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Review
. 2022 Jan;63(Suppl):S43-S55.
doi: 10.3349/ymj.2022.63.S43.

Digital Biomarkers in Living Labs for Vulnerable and Susceptible Individuals: An Integrative Literature Review

YouHyun Park  1 , Tae-Hwa Go  1 , Se Hwa Hong  1 , Sung Hwa Kim  1 , Jae Hun Han  1 , Yeongsil Kang  2 , Dae Ryong Kang  1   3
Affiliations
Review

Digital Biomarkers in Living Labs for Vulnerable and Susceptible Individuals: An Integrative Literature Review

YouHyun Park et al. Yonsei Med J. 2022 Jan.

Abstract

Purpose: The study aimed to identify which digital biomarkers are collected and which specific devices are used according to vulnerable and susceptible individual characteristics in a living-lab setting.

Materials and methods: A literature search, screening, and appraisal process was implemented using the Web of Science, Pubmed, and Embase databases. The search query included a combination of terms related to "digital biomarkers," "devices that collect digital biomarkers," and "vulnerable and susceptible groups." After the screening and appraisal process, a total of 37 relevant articles were obtained.

Results: In elderly people, the main digital biomarkers measured were values related to physical activity. Most of the studies used sensors. The articles targeting children aimed to predict diseases, and most of them used devices that are simple and can induce some interest, such as wearable device-based smart toys. In those who were disabled, digital biomarkers that measured location-based movement for the purpose of diagnosing disabilities were widely used, and most were measured by easy-to-use devices that did not require detailed explanations. In the disadvantaged, digital biomarkers related to health promotion were measured, and various wearable devices, such as smart bands and headbands were used depending on the purpose and target.

Conclusion: As the digital biomarkers and devices that collect them vary depending on the characteristics of study subjects, researchers should pay attention not only to the purpose of the study but also the characteristics of study subjects when collecting and analyzing digital biomarkers from living labs.

Keywords: Digital biomarkers; living lab; susceptible individual; vulnerable individual.

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1. PRISMA flow diagram of study selection. PRISMA, preferred reporting items for systematic reviews and meta-analyses.
Fig. 2
Fig. 2. Number of articles by country and year.
See this image and copyright information in PMC

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