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. 2022 Nov;306(5):1455-1461.
doi: 10.1007/s00404-022-06404-8. Epub 2022 Jan 18.

Cardiovascular outcome of former late-onset small-for-gestational-age children at 1 year of age: CURIOSA study

Annette Wacker-Gussmann  1   2 , Jana Engelhard  3 , Renate Oberhoffer-Fritz  3 , Judith Schopen  3 , Peter Ewert  4 , Javier U Ortiz  5 , Bernhard Haller  6 , Oliver Graupner  5 , Silvia M Lobmaier  5
Affiliations

Cardiovascular outcome of former late-onset small-for-gestational-age children at 1 year of age: CURIOSA study

Annette Wacker-Gussmann et al. Arch Gynecol Obstet. 2022 Nov.

Abstract

Objective: Late-onset small-for-gestational-age (SGA) fetuses usually show normal uterine artery Doppler and were long considered to have a good peri- and postnatal outcome. Recently, these fetuses were identified to have a risk factor for cardiovascular disease. The aim of our study was to evaluate former SGA children concerning their cardiovascular risk and nutrition behavior at the age of 1 year.

Methods: We performed a prospective longitudinal cohort study at the University Hospital "Klinikum rechts der Isar" of the Technical University of Munich. Singleton pregnancies from 32 weeks with suspicion of SGA and healthy control pregnancies were included.

Results: A total of 100 former SGA children and 113 controls with normal weight (AGA) were examined at 1 year of age. Drop-out for 1-year follow-up was 27%. SGA children had significantly higher systolic (92.8 ± 9.8 mmHg vs. 87.5 ± 10.7 mmHg, p = 0.001), diastolic (63.1 ± 8.5 mmHg vs. 60.0 ± 10.3 mmHg, p = 0.028) and mean (73.0 ± 7.8 vs. 69.2 ± 9.7 mmHg, p = 0.004) blood pressure than AGA children. Comparing two breastfeeding periods (0-4 months vs. > 7 months), a downward trend in blood pressure values for longer breastfeeding periods was shown.

Conclusion: Our study showed that even late-onset small-for-gestational-age fetuses seem to have cardiovascular problems, although they were previously thought to be "healthy". Up to now, blood pressure measurement is not part of indicated health checks in former SGA or even fetal growth-restricted children which should be changed. Further studies are needed to investigate cardiovascular prevention programs in children.

Keywords: Blood pressure; Children; Fetal programming; Late-onset small for gestational age; Prenatal.

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References

    1. Crispi F, Crovetto F, Gratacos E (2018) Intrauterine growth restriction and later cardiovascular function. Early Human Dev 126:23–27 - DOI
    1. Hecher K, Bilardo CM, Stigter RH, Ville Y, Hackeloer BJ, Kok HJ, Senat MV, Visser GH (2001) Monitoring of fetuses with intrauterine growth restriction: a longitudinal study. Ultrasound Obs Gynecol 18:564–570 - DOI
    1. Gordijn SJ, Beune IM, Thilaganathan B, Papageorghiou A, Baschat AA, Baker PN, Silver RM, Wynia K, Ganzevoort W (2016) Consensus definition of fetal growth restriction: a Delphi procedure. Ultrasound obs Gynecol 48:333–339 - DOI
    1. Figueras F, Oros D, Cruz-Martinez R, Padilla N, Hernandez-Andrade E, Botet F, Costas-Moragas C, Gratacos E (2009) Neurobehavior in term, small-for-gestational age infants with normal placental function. Pediatrics 124:e934–e941 - DOI
    1. Savchev S, Sanz-Cortes M, Cruz-Martinez R, Arranz A, Botet F, Gratacos E, Figueras F (2013) Neurodevelopmental outcome of full-term small-for-gestational-age infants with normal placental function. Ultrasound Obs Gynecol 42:201–206 - DOI

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