Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb 1;208(3):531-537.
doi: 10.4049/jimmunol.2100961.

Minimal Information about MHC Multimers (MIAMM)

Randi Vita  1 , Apurva Mody  2 , James A Overton  3 , Soren Buus  4 , Stephen T Haley  5 , Alessandro Sette  2   6 , Vamsee Mallajosyula  7 , Mark M Davis  7   8 , Dale L Long  9 , Richard A Willis  9 , Bjoern Peters  2   6 , John D Altman  9   10
Affiliations

Minimal Information about MHC Multimers (MIAMM)

Randi Vita et al. J Immunol. .

Abstract

With the goal of improving the reproducibility and annotatability of MHC multimer reagent data, we present the establishment of a new data standard: Minimal Information about MHC Multimers (https://miamm.lji.org/). Multimers are engineered reagents composed of a ligand and a MHC, which can be represented in a standardized format using ontology terminology. We provide an online Web site to host the details of the standard, as well as a validation tool to assist with the adoption of the standard. We hope that this publication will bring increased awareness of Minimal Information about MHC Multimers and drive acceptance, ultimately improving the quality and documentation of multimer data in the scientific literature.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Multimer Validation Tool.
This freely available web tool allows users to validate the terminology used for their multimers at https://multimer.lji.org. Examples are provided and terms may be validated one at a time or uploaded as a set.
See this image and copyright information in PMC

References

    1. McHeyzer-Williams MG, Altman JD, Davis MM 1996. Enumeration and characterization of memory cells in the TH compartment. Immunol Rev 150: 5–21. - PubMed
    1. Vita R, Vasilevsky N, Bandrowski A, Haendel M, Sette A, Peters B 2016. Reproducibility and Conflicts in Immune Epitope Data. Immunology 147(3): 349–354. - PMC - PubMed
    1. Vasilevsky NA, Brush MH, Paddock H, Ponting L, Tripathy SJ, Larocca GM, Haendel MA 2013. On the reproducibility of science: unique identification of research resources in the biomedical literature. PeerJ 1:e148: 1–22. - PMC - PubMed
    1. Vita R, Mahajan S, Overton JA, Dhanda SK, Martini S, Cantrell JR, Wheeler DK, Sette A, Peters B 2019. The Immune Epitope Database (IEDB): 2018 update. Nucleic Acids Res 47: D339–D343. - PMC - PubMed
    1. Wilkinson MD, Dumontier M, Aalbersberg IJ, Appleton G, Axton M, Baak A, Blomberg N, Boiten JW, da Silva Santos LB, Bourne PE, Bouwman J, Brookes AJ, Clark T, Crosas M, Dillo I, Dumon O, Edmunds S, Evelo CT, Finkers R, Gonzalez-Beltran A, Gray AJG, Groth P, Goble C, Grethe JS, Heringa J, ‘t Hoen PAC, Hooft R, Kuhn T, Kok R, Kok J, Lusher SJ, Martone ME, Mons A, Packer AL, Persson B, Rocca-Serra P, Roos M, van Schaik R, Sansone SA, Schultes E, Sengstag T, Slater T, Strawn G, Swertz MA, Thompson M, van der Lei J, van Mulligen E, Velterop J, Waagmeester A, Wittenburg P, Wolstencroft K, Zhao J, and Mons B 2016. The FAIR Guiding Principles for scientific data management and stewardship. Sci Data 15;3:160018: 1–9. - PMC - PubMed

Publication types

MeSH terms