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Case Reports
. 2022 Jan-Dec:10:23247096211073258.
doi: 10.1177/23247096211073258.

Autoimmune Hemolytic Anemia After mRNA COVID Vaccine

Zainab Fatima  1 , Blair R A Reece  1 , J Suzanne Moore  1 , Robert T Means Jr  1
Affiliations
Case Reports

Autoimmune Hemolytic Anemia After mRNA COVID Vaccine

Zainab Fatima et al. J Investig Med High Impact Case Rep. 2022 Jan-Dec.

Abstract

Discussion of the hematologic complications of vaccination for severe acute respiratory syndrome coronavirus-2 (COVID-19) has primarily focused on the development of vaccine-associated immune thrombosis with thrombocytopenia (VITT). Other hematologic complications are uncommon. We report the case of a patient who developed immunoglobulin G (IgG)-mediated autoimmune hemolytic anemia (AIHA) after the Moderna COVID-19 messenger ribonucleic acid (mRNA) vaccine.

Keywords: COVID; COVID vaccine; autoimmune hemolytic anemia; hematology oncology; hemolysis; rheumatology.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
The relationship between the messenger ribonucleic acid vaccine and hemolytic parameters.
See this image and copyright information in PMC

References

    1. Baden LR, El Sahly HM, Essink B, et al.. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021;384(5):403-416. - PMC - PubMed
    1. Franchini M, Liumbruno GM, Pezzo M. COVID-19 vaccine-associated immune thrombosis and thrombocytopenia (VITT): diagnostic and therapeutic recommendations for a new syndrome. Eur J Haematol. 2021;107(2):173-180. - PMC - PubMed
    1. Harada Y, Yamamoto H, Sato M, Kodaira M, Kono T. Autoimmune hemolytic anemia during adalimumab treatment for plaque psoriasis. Intern Med. 2015;54(9):1103-1104. - PubMed
    1. Nagashima T, Minota S. Autoimmune hemolytic anemia induced by adalimumab. Intern Med. 2016;55(6):715. - PubMed
    1. Gaignard ME, Lieberherr S, Schoenenberger A, Benz R. Autoimmune hematologic disorders in two patients after mRNA COVID-19 vaccine. Hemasphere. 2021;5(8):e618. - PMC - PubMed

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