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. 2022 Feb;10(2):259-271.
doi: 10.1158/2326-6066.CIR-21-0119. Epub 2022 Jan 19.

Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16+ Cancers

Lauren E Colbert  1 , Molly B El  2 , Erica J Lynn  2 , Julianna Bronk  2 , Tatiana V Karpinets  3 , Xiaogang Wu  3 , Bhavana V Chapman  2 , Travis T Sims  4 , Daniel Lin  2 , Ramez Kouzy  2 , Julie Sammouri  2 , Greyson Biegert  2 , Andrea Y Delgado Medrano  2 , Adilene Olvera  5 , K Jagannadha Sastry  6 , Patricia J Eifel  2 , Anuja Jhingran  2 , Lilie Lin  2 , Lois M Ramondetta  4 , Andrew P Futreal  3 , Amir A Jazaeri  4 , Kathleen M Schmeler  4 , Jingyan Yue  7 , Aparna Mitra  2 , Kyoko Yoshida-Court  2 , Jennifer A Wargo  3 , Travis N Solley  2 , Venkatesh Hegde  6 , Sita S Nookala  6 , Ananta V Yanamandra  6 , Stephanie Dorta-Estremera  7   8 , Geena Mathew  2 , Rohit Kavukuntla  2 , Cassidy Papso  2 , Mustapha Ahmed-Kaddar  2 , Minsoo Kim  2 , Jianhua Zhang  3 , Alexandre Reuben  6 , Emma B Holliday  2 , Bruce D Minsky  2 , Albert C Koong  2 , Eugene J Koay  2 , Prajnan Das  2 , Cullen M Taniguchi  2 , Ann Klopp  1
Affiliations

Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16+ Cancers

Lauren E Colbert et al. Cancer Immunol Res. 2022 Feb.

Abstract

Human papillomavirus (HPV) infection causes 600,000 new cancers worldwide each year. HPV-related cancers express the oncogenic proteins E6 and E7, which could serve as tumor-specific antigens. It is not known whether immunity to E6 and E7 evolves during chemoradiotherapy or affects survival. Using T cells from 2 HPV16+ patients, we conducted functional T-cell assays to identify candidate HPV-specific T cells and common T-cell receptor motifs, which we then analyzed across 86 patients with HPV-related cancers. The HPV-specific clones and E7-related T-cell receptor motifs expanded in the tumor microenvironment over the course of treatment, whereas non-HPV-specific T cells did not. In HPV16+ patients, improved recurrence-free survival was associated with HPV-responsive T-cell expansion during chemoradiotherapy.

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