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. 2022 Dec;71(12):2601-2602.
doi: 10.1136/gutjnl-2021-326853. Epub 2022 Jan 19.

Alcohol consumption and smoking dose-dependently and synergistically worsen local pancreas damage

Andrea Szentesi  1   2 , Nelli Farkas  1   3 , Zoltán Sipos  1 , Péter Mátrai  1 , Áron Vincze  4 , Ferenc Izbéki  5 , Andrea Párniczky  1   6 , Péter Hegyi  7   8   9 ; Hungarian Pancreatic Study Group
Collaborators, Affiliations

Alcohol consumption and smoking dose-dependently and synergistically worsen local pancreas damage

Andrea Szentesi et al. Gut. 2022 Dec.
No abstract available

Keywords: alcohol; pancreatitis.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Dose dependency in alcohol consumption and smoking in AP. (A) Light and heavy alcohol consumption and smoking groups and definitions. (B, C) Amylase and lipase levels on admission. (D) Prevalence of RAP and CP (%). (E) Proportion of local complications (%). (F, G) Amylase and lipase levels on admission. (H) Prevalence of RAP and CP (%). *P<0.001, **p=0.003. Pearson’s χ2 test and the Kruskal-Wallis rank sum tests were used. AP, acute pancreatitis; CP, chronic pancreatitis; RAP, recurrent AP.
Figure 2
Figure 2
Combined alcohol consumption and smoking groups in AP. (A) Groups. (B) Sex. *P<0.001 in all comparisons. (C) Age. *P<0.001 or p=0.001 in all comparisons. (D) Severity. Moderately severe *p=0.003 vs NS–ND. P=0.022 vs S–ND. (E) On admission amylase level. *P<0.001 vs NS–ND. **P<0.003 vs NS–ND. ***p<0.001 vs NS–ND, NS–D and S–ND. (F) On-admission lipase level. *P<0.003 vs NS–ND, p<0.006 vs NS–D. **P<0.001 vs NS–ND and NS–D. (G) Prevalence of recurrent AP. *P=0.003 vs NS–ND. **p=0.04 vs NS–D. p<0.001 vs NS–ND. (H) Prevalence of chronic pancreatitis. *P<0.001 vs NS–ND, NS–D. Pearson’s χ2 test and the Kruskal-Wallis rank sum tests were used. AP, acute pancreatitis; NS–D: non-smoking–drinking; NS–ND: non-smoking–non-drinking; S–D: smoking–drinking; S-ND: smoking–non-drinking.
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References

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