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. 2022 Jan 11:10:e12630.
doi: 10.7717/peerj.12630. eCollection 2022.

CTRP3 as a novel biomarker in the plasma of Saudi children with autism

Manan Alhakbany #  1 , Laila Al-Ayadhi  1   2 , Afaf El-Ansary #  2   3   4
Affiliations

CTRP3 as a novel biomarker in the plasma of Saudi children with autism

Manan Alhakbany et al. PeerJ. .

Abstract

Background: C1q/tumor necrosis factor-related protein-3 (CTRP3) has diverse functions: anti-inflammation, metabolic regulation, and protection against endothelial dysfunction.

Methods: The plasma level of CTRP3 in autistic patients (n = 32) was compared to that in controls (n = 37) using ELISA.

Results: CTRP3 was higher (24.7% with P < 0.05) in autistic patients than in controls. No association was observed between CTRP3 and the severity of the disorder using the Childhood Autism Rating Scale (CARS). A positive correlation between CARs and the age of patients was reported. Receiver operating characteristic (ROC) analysis demonstrated a low area under the curve (AUC) for all patients (0.636). Low AUCs were also found in the case of severe patients (0.659) compared to controls, but both values were statistically significant (P ≤ 0.05). Despite the small sample size, we are the first to find an association between CTRP3 and autism spectrum disorder (ASD).

Keywords: Autism spectrum disorder; Biomarker; C1q/tumor necrosis factor (TNF)-related protein (CTRP3); Childhood autism rating scale; Receiver operating characteristic (ROC).; Receiver operating characteristics (ROC).

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1. Boxplot to show the data distribution of CTRP3 in the control and patients’ groups (A), and data distribution of CTRP3 in mild to moderate and sever autistic groups (B).
Figure 2
Figure 2. Correlation between CARS and Age with best fit line curve (negative correlation).
See this image and copyright information in PMC

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