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. 2022 Aug;37(6):2077-2088.
doi: 10.1007/s11011-021-00896-0. Epub 2022 Jan 20.

Taurine supplementation improves hippocampal metabolism in immature rats with intrauterine growth restriction (IUGR) through protecting neurons and reducing gliosis

Qiong Fang  1 , Jing Liu  2   3 , Lang Chen  1 , Qiaobin Chen  1 , Yan Wang  4 , Zuanfang Li  5 , Wei Fu  6 , Ying Liu  6
Affiliations

Taurine supplementation improves hippocampal metabolism in immature rats with intrauterine growth restriction (IUGR) through protecting neurons and reducing gliosis

Qiong Fang et al. Metab Brain Dis. 2022 Aug.

Abstract

Taurine as an essential amino acid in the brain could play an important role in protecting the fetal brain of intrauterine growth restriction (IUGR). The hippocampus with IUGR showed neural metabolic disorder and structure changed that affected memory and learning ability. This study was aimed to identify the effect of taurine supplementation on the metabolism alterations and cellular composition changes of the hippocampus in IUGR immature rats. Metabolite concentrations were determined by magnetic resonance spectroscopy (MRS) in the hippocampus of juvenile rats with IUGR following taurine supplementation with antenatal or postnatal supply. The composition of neural cells in the hippocampus was observed by immunohistochemical staining (IHC) and western blotting (WB). Antenatal taurine supplementation increased the ratios of N-acetylaspartate (NAA) /creatine (Cr) and glutamate (Glu) /Cr of the hippocampus in the IUGR immature rats, but reduced the ratios of choline (Cho) /Cr and myoinositol (mI) /Cr. At the same time, the protein expression of NeuN in the IUGR rats was increased through intrauterine taurine supplementation, and the GFAP expression was reduced. Especially the effect of antenatal taurine was better than postpartum. Furthermore, there existed a positive correlation between the NAA/Cr ratio and the NeuN protein expression (R = 0.496 p < 0.001 IHC; R = 0.568 p < 0.001 WB), the same results existed in the relationship between the mI/Cr ratio and the GFAP protein expression (R = 0.338 p = 0.019 IHC; R = 0.440 p = 0.002 WB). Prenatal taurine supplementation can better improve hippocampal neuronal metabolism by increasing NAA / Cr ratio related to the number of neurons and reducing Cho / Cr ratio related to the number of glial cells.

Keywords: Hippocampus; Immature rats; Intrauterine growth restriction; Magnetic resonance spectroscopy; Taurine.

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References

    1. Amaral AI, Meisingset TW, Kotter MR, Sonnewald U (2013) Metabolic aspects of neuron-oligodendrocyte-astrocyte interactions. Front Endocrinol (Lausanne) 4:54. https://doi.org/10.3389/fendo.2013.00054 - DOI
    1. Batista TM, Ribeiro RA, Amaral AG, de Oliveira CA, Boschero AC, Carneiro EM (2012) Taurine supplementation restores glucose and carbachol-induced insulin secretion in islets from low-protein diet rats: involvement of Ach-M3R, Synt 1 and SNAP-25 proteins. J Nutr Biochem 23:306–312. https://doi.org/10.1016/j.jnutbio.2010.12.012 - DOI - PubMed
    1. Bell T, Boudes ES, Loo RS, Barker GJ, Lythgoe DJ, Edden R, Lebel RM, Wilson M, Harris AD (2020) In vivo Glx and Glu measurements from GABA-edited MRS at 3 T. NMR Biomed:e4245. https://doi.org/10.1002/nbm.4245
    1. Bendix I, Miller SL, Winterhager E (2020) Editorial: causes and consequences of intrauterine growth restriction. Front Endocrinol (Lausanne) 11:205. https://doi.org/10.3389/fendo.2020.00205 - DOI
    1. Boschen KE, Criss KJ, Palamarchouk V, Roth TL, Klintsova AY (2015) Effects of developmental alcohol exposure vs. intubation stress on BDNF and TrkB expression in the hippocampus and frontal cortex of neonatal rats. Int J Dev Neurosci 43:16–24. https://doi.org/10.1016/j.ijdevneu.2015.03.008 - DOI - PubMed - PMC

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