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. 2022 Feb;17(3):167-179.
doi: 10.2217/nnm-2021-0229. Epub 2022 Jan 20.

Solid lipid nanoparticles loaded with curcumin: development and in vitro toxicity against CT26 cells

Rayane Ganassin  1   2 , Victor Carlos Mello da Silva  1   2 , Victor Hugo Sousa Araujo  1   2 , Giulia Rosa Tavares  1   2 , Patrícia Bento da Silva  2 , Paolin Rocio Cáceres-Vélez  2   3   4 , Joaquin E Martínez Porcel  3 , Mosar Corrêa Rodrigues  1   2 , Patrizia Andreozzi  3 , Richard Perosa Fernandes  5 , Bruno Fonseca-Santos  6 , Sergio Moya  3 , Ricardo Bentes Azevedo  2 , Marlus Chorilli  7 , Luis Alexandre Muehlmann  1   2
Affiliations

Solid lipid nanoparticles loaded with curcumin: development and in vitro toxicity against CT26 cells

Rayane Ganassin et al. Nanomedicine (Lond). 2022 Feb.

Abstract

Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro. Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media.

Keywords: cancer; colloid; colon adenocarcinoma; drug delivery; murumuru butter.

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