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. 2022 Jan 17;20(1):77.
doi: 10.3390/md20010077.

New Tripeptide Derivatives Asperripeptides A-C from Vietnamese Mangrove-Derived Fungus Aspergillus terreus LM.5.2

Elena V Girich  1 , Anton B Rasin  1 , Roman S Popov  1 , Ekaterina A Yurchenko  1 , Ekaterina A Chingizova  1 , Phan Thi Hoai Trinh  2 , Ngo Thi Duy Ngoc  2 , Mikhail V Pivkin  1 , Olesya I Zhuravleva  3 , Anton N Yurchenko  1
Affiliations

New Tripeptide Derivatives Asperripeptides A-C from Vietnamese Mangrove-Derived Fungus Aspergillus terreus LM.5.2

Elena V Girich et al. Mar Drugs. .

Abstract

Three new tripeptide derivatives asterripeptides A-C (1-3) were isolated from Vietnamese mangrove-derived fungus Aspergillus terreus LM.5.2. Structures of isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of all stereocenters were determined using the Murfey's method. The isolated compounds 1-3 contain a rare fungi cinnamic acid residue. The cytotoxicity of isolated compounds against several cancer cell lines and inhibition ability of sortase A from Staphylococcus aureus of asterripeptides A-C were investigated.

Keywords: cinnamic acid; cytotoxicity; diketopiperazines; mangrove-derived fungi; marine-derived fungi; secondary metabolites; sortase A; tripeptide derivatives.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
The structure of isolated 1–3 compounds.
Figure 2
Figure 2
The key HMBC (a) and 1H-1H COSY and ROESY (b) correlation of 1.
Figure 3
Figure 3
The key HMBC (a) and 1H-1H COSY and ROESY (b) correlations of 2.
Figure 4
Figure 4
The key HMBC (a) and 1H-1H COSY and ROESY (b) correlations of 3.
Figure 5
Figure 5
Effects of asterripeptides A–C (1–3) on the enzymatic activity of sortase A. Reaction kinetics of sortase A in the presence of isolated compounds (80 μM) and selective inhibitor 4-(hydroxymercuri)benzoic acid (PCMB) are at the same level of substrate concentration. DMSO (0.8%) was used as a vehicle.
See this image and copyright information in PMC

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