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Review
. 2021;27(4):11-16.
doi: 10.33529/ANGIO2021410.

[Study of gene expression in patients with peripheral artery disease]

[Article in Russian]
R E Kalinin  1 , I A Suchkov  1 , E I Shumskaia  1 , N D Mzhavanadze  1 , M M Uporov  1 , M S Nekliudov  1
Affiliations
Review

[Study of gene expression in patients with peripheral artery disease]

[Article in Russian]
R E Kalinin et al. Angiol Sosud Khir. 2021.

Abstract
in English, Russian

Currently, there are no widely used available techniques for reliable prognosis of the onset and course of peripheral artery disease. Working out of optimal test systems including genetic ones for assessment of risks for the development of the disease, its progression or development of complications in patients with peripheral atherosclerosis is an important mission of modern medicine. This article deals with a promising technique of genetic studies in patients with peripheral artery disease, i. e., study of gene expression. Also provided herein is a literature review devoted to the main techniques used for the analysis of the profile of gene expression. This is followed by evaluating the possibility of using DNA chips, as well as describing the state of the art and unsolved problems of studying gene expression in patients with peripheral artery disease.

В настоящее время не существует широко распространенных доступных методик для достоверного прогнозирования возникновения и течения заболевания периферических артерий. Разработка оптимальных тест-систем, в том числе генетических, для оценки рисков развития заболевания, его прогрессирования либо развития осложнений у пациентов с периферическим атеросклерозом является важной задачей современной медицины. В данной статье рассматривается перспективный метод генетических исследований у пациентов с заболеваниями периферических артерий – изучение экспрессии генов. В работе представлен литературный обзор, посвященный основным методикам, которые применяются для анализа профиля экспрессии генов, проводится оценка возможности использования ДНК-чипов. Описываются современное состояние и нерешенные вопросы изучения экспрессии генов у больных с заболеваниями периферических артерий.

Keywords: DNA chips; gene expression; intermittent claudication; obliterating atherosclerosis of lower limb arteries; peripheral artery disease.

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References

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