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Review
. 2022 Jan 13;7(1):9.
doi: 10.3390/tropicalmed7010009.

SARS-CoV-2 mRNA Vaccine Breakthrough Infections in Fully Vaccinated Healthcare Personnel: A Systematic Review

Caterina Ledda  1 , Claudio Costantino  2 , Giuseppe Motta  3 , Rosario Cunsolo  4 , Patrizia Stracquadanio  5 , Giuseppe Liberti  6 , Helena C Maltezou  7 , Venerando Rapisarda  1   5
Affiliations
Review

SARS-CoV-2 mRNA Vaccine Breakthrough Infections in Fully Vaccinated Healthcare Personnel: A Systematic Review

Caterina Ledda et al. Trop Med Infect Dis. .

Abstract

The number of people vaccinated against COVID-19 increases worldwide every day; however, it is important to study the risk of breakthrough infections in vaccinated individuals at high risk of exposure such as healthcare personnel (HCP). A systematic literature review (SLR) applying the PRISMA declaration and the PECOS format using the following entry terms was used: "Health Personnel OR Healthcare Worker OR Healthcare Provider OR Healthcare Personnel AND breakthrough OR infection after vaccine*". The research was carried out utilizing the following databases: SCOPUS, PubMed, Embase, and Web of Sciences. An overall very low incidence of post-vaccination breakthrough infections was found, ranging from 0.011 to 0.001 (per 100 individuals at risk). Our findings further support the published high effectiveness rates of mRNA vaccines in preventing SARS-CoV-2 infections among fully vaccinated HCP. Additional studies are needed to define the duration of the vaccine-induced protection among HCP.

Keywords: BNT162b2; COVID-19; SARS-CoV-2; TAK-919; asymptomatic infection; healthcare personnel; mRNA-1273; pandemic; post-vaccination; vaccination.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Graph illustrating included and excluded studies in the SLR.
See this image and copyright information in PMC

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