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. 2022 Jan 19;110(2):175-177.
doi: 10.1016/j.neuron.2021.12.025.

Sympathetic yet painful: Autonomic innervation drives cluster firing of somatosensory neurons

Matan Geron  1 , Adrien Tassou  1 , Grégory Scherrer  2
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Sympathetic yet painful: Autonomic innervation drives cluster firing of somatosensory neurons

Matan Geron et al. Neuron. .
Free article

Abstract

In this issue of Neuron, Zheng et al. (2021) report synchronized cluster firing of dorsal root ganglion (DRG) neurons that correlates with spontaneous pain in the setting of nerve injury. The authors' findings further suggest that sympathetic sprouting in the DRG plays a key role in this phenomenon.

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