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Comment
. 2022 Jan 19;110(2):178-180.
doi: 10.1016/j.neuron.2021.12.026.

KCNQ channel PIP2 modulation: Two loose links, three rings, and a twist

Edward C Cooper  1 , Timothy Abreo  2 , Baouyen Tran  3
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KCNQ channel PIP2 modulation: Two loose links, three rings, and a twist

Edward C Cooper et al. Neuron. .
Free article

Abstract

In this issue of Neuron, structures by Zheng et al. (2021) provide a newly comprehensive view of KCNQ channel interaction with phosphatidyl inositol 4,5-bisphosphate (PIP2), yielding insights for modulatory mechanisms of channels implicated in deafness, epilepsy, autism, and intellectual disability.

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