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Editorial
. 2022 Apr;149(4):1223-1224.
doi: 10.1016/j.jaci.2022.01.002. Epub 2022 Jan 17.

Profiling natural killers in COVID-19

Affiliations
Editorial

Profiling natural killers in COVID-19

Emily M Mace. J Allergy Clin Immunol. 2022 Apr.
No abstract available

Keywords: COVID-19; Natural killer cells; SARS-CoV-2; cytotoxicity.

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Figures

Fig 1
Fig 1
Graphical representation of the functional and phenotypic features of circulating NK cells identified by Krämer et al.

Comment on

  • Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
    Krämer B, Knoll R, Bonaguro L, ToVinh M, Raabe J, Astaburuaga-García R, Schulte-Schrepping J, Kaiser KM, Rieke GJ, Bischoff J, Monin MB, Hoffmeister C, Schlabe S, De Domenico E, Reusch N, Händler K, Reynolds G, Blüthgen N, Hack G, Finnemann C, Nischalke HD, Strassburg CP, Stephenson E, Su Y, Gardner L, Yuan D, Chen D, Goldman J, Rosenstiel P, Schmidt SV, Latz E, Hrusovsky K, Ball AJ, Johnson JM, Koenig PA, Schmidt FI, Haniffa M, Heath JR, Kümmerer BM, Keitel V, Jensen B, Stubbemann P, Kurth F, Sander LE, Sawitzki B; Deutsche COVID-19 OMICS Initiative (DeCOI); Aschenbrenner AC, Schultze JL, Nattermann J. Krämer B, et al. Immunity. 2021 Nov 9;54(11):2650-2669.e14. doi: 10.1016/j.immuni.2021.09.002. Epub 2021 Sep 4. Immunity. 2021. PMID: 34592166 Free PMC article.

References

    1. Yu J., Tostanoski L.H., Peter L., Mercado N.B., McMahan K., Mahrokhian S.H., et al. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science. 2020;369:806–811. - PMC - PubMed
    1. Krämer B., Knoll R., Bonaguro L., ToVinh M., Raabe J., Astaburuaga-Garcia R., et al. Early IFN-alpha signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19. Immunity. 2021;54:2650–2669.e14. - PMC - PubMed
    1. Xu G., Qi F., Li H., Yang Q., Wang H., Wang X., et al. The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing. Cell Discov. 2020;6:73. - PMC - PubMed
    1. Wilk A.J., Rustagi A., Zhao N.Q., Roque J., Martinez-Colon G.J., McKechnie J.L., et al. A single-cell atlas of the peripheral immune response in patients with severe COVID-19. Nat Med. 2020;26:1070–1076. - PMC - PubMed
    1. Smith S.L., Kennedy P.R., Stacey K.B., Worboys J.D., Yarwood A., Seo S., et al. Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing. Blood Adv. 2020;4:1388–1406. - PMC - PubMed