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. 1986;2(1-2):125-7.
doi: 10.3109/10715768609088063.

Influence of the iron chelating agent desferrioxamine on two rat inflammatory models

R Hirschelmann  1 , H Bekemeier
Affiliations

Influence of the iron chelating agent desferrioxamine on two rat inflammatory models

R Hirschelmann et al. Free Radic Res Commun. 1986.

Abstract

The carrageenin rat paw edema was dose-dependently inhibited by i.v. and i.m. administration of desferrioxamine, a specific iron chelating agent. Therefore, iron-catalyzed formation of free radicals might be involved in this acute inflammatory reaction. In contrast, no antiinflammatory activity of desferrioxamine could be seen in rat adjuvant arthritis, a model of subacute and chronic inflammation.

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