Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

Abstract

There is growing interest in single nucleotide polymorphisms (SNPs) in the genes of microRNAs (miRNAs), which could be associated with susceptibility to colorectal cancer (CRC) and therefore for prognosis of the disease and/or treatment response. Moreover, these miRNAs-SNPs could serve as new, low-invasive biomarkers for early detection of CRC. In the present article, we performed a thorough review of different SNPs, which were investigated for a correlation with the CRC risk, prognosis, and treatment response. We also analyzed the results from different meta-analyses and the possible reasons for reported contradictory findings, especially when different research groups investigated the same SNP in a gene for a particular miRNA. This illustrates the need for more case-control studies involving participants with different ethnic backgrounds. According to our review, three miRNAs-SNPs-miR-146a rs2910164, miR-27a rs895819 and miR-608 rs4919510-appear as promising prognostic, diagnostic and predictive biomarkers for CRC, respectively.

Keywords: SNP; colorectal cancer; miRNA; single nucleotide polymorphism.

Figure 1

Sequence variations in mature miRNAs. Single nucleotide polymorphisms (SNPs) in miRNA “seed” sequence may lead to a change in miRNA complementarity. Consequently, this may dysregulate multiple cellular pathways. On the other hand, SNPs outside the “seed” region may increase or decrease the efficiency in miRNA binding to mRNA.