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Review
. 2021 Dec 27;11(1):27.
doi: 10.3390/antibiotics11010027.

Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations

Paula Rojas-Garcia  1 , Simon van der Pol  2 , Antoinette D I van Asselt  2   3 , Maarten J Postma  2   4 , Roberto Rodríguez-Ibeas  1 , Carmelo A Juárez-Castelló  1 , Marino González  1 , Fernando Antoñanzas  1
Affiliations
Review

Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations

Paula Rojas-Garcia et al. Antibiotics (Basel). .

Abstract

Introduction: Sepsis is a serious and expensive healthcare problem, when caused by a multidrug-resistant (MDR) bacteria mortality and costs increase. A reduction in the time until the start of treatment improves clinical results. The objective is to perform a systematic review of economic evaluations to analyze the cost-effectiveness of diagnostic methods in sepsis and to draw lessons on the methods used to incorporate antimicrobial resistance (AMR) in these studies.

Material and methods: the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and the Consolidated Health Economic Evaluation Reporting standards (CHEERS) checklist was used to extract the information from the texts.

Results: A total of 16 articles were found. A decision model was performed in 14. We found two ways to handle resistance while modelling: the test could identify infections caused by a resistant pathogen or resistance-related inputs, or outcomes were included (the incidence of AMR in sepsis patients, antibiotic use, and infection caused by resistant bacterial pathogens).

Conclusion: Using a diagnostic technique to detect sepsis early on is more cost-effective than standard care. Setting a direct relationship between the implementation of a testing strategy and the reduction of AMR cases, we made several assumptions about the efficacy of antibiotics and the length-of-stay of patients.

Keywords: AMR; antibiotics; diagnostic testing; sepsis; systematic review.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram.
See this image and copyright information in PMC

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