[Pharmacokinetics of ticarcillin in patients with normal and impaired renal function (author's transl)]

Abstract

Elimination half-life of ticarcillin was measured in 61 patients with different levels of renal function after intravenous rapid infusion (1--20 g). Assuming a single-compartment model for elimination, there was in those without renal disease a half-life of approximately 71 minutes, although there were considerable individual variations. In patients with impaired renal function (glomerular filtration rate 30--60 ml/min) the values were between 60 and 120 minutes, while in one patient with a filtration rate of 2.08 ml/min it was over 400 min. If there is a correlation between dose and half-life, it was obscured by the individual variations. Distribution volume was 21 1/100 kg body-weight.