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. 2022 Jan 1;9(1):35.
doi: 10.3390/children9010035.

Meckel's Diverticulum in Children: A Monocentric Experience and Mini-Review of Literature

Matthias Nissen  1 , Volker Sander  1 , Phillip Rogge  1 , Mohamad Alrefai  1 , Ralf-Bodo Tröbs  2
Affiliations

Meckel's Diverticulum in Children: A Monocentric Experience and Mini-Review of Literature

Matthias Nissen et al. Children (Basel). .

Abstract

Vitelline duct anomalies (VDA, including Meckel's diverticulum (MD)) result from failed embryologic obliteration. This study aimed for characteristics in symptomatic versus asymptomatic VDA, analyzing clinico-laboratory data from 73 children, aged 1 day to 17 years, treated at a tertiary Pediatric Surgery Institution from 2002-2017. A male preponderance was obtained (ratio 3.6:1). MD accounted for 85% of VDA. Incidence of symptomatic VDA decreased with older age. Leading symptoms were intestinal obstruction and hemorrhage. Mucosal heterotopia (present in 39% of symptomatic MD) was associated with anemia and lowered CRP-levels. On ROC-analysis, hemoglobin < 8.6 g/dL, CRP < 0.6 mg/dL and MD distance to ileocecal valve >40 cm were predictors of ectopic tissue in symptomatic MD. Our data confirmed known characteristics as male preponderance, declined incidence of symptomatic cases with age and predominance of gastric ectopia in symptomatic MD. Moreover, anemia and prolonged distance of MD to ileocecal valve were predictors of ectopic mucosa in symptomatic MD.

Keywords: Meckel’s diverticulum; enteric hemorrhage; gastric heterotopia; intussusception; pediatric vitelline duct anomalies.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Huang C.C., Lai M.W., Hwang F.M., Yeh Y.C., Chen S.Y., Kong M.S., Lai J.Y., Chen J.C., Ming Y.C. Diverse presentations in pediatric Meckel’s diverticulum: A review of 100 cases. Pediatr. Neonatol. 2014;55:369–375. doi: 10.1016/j.pedneo.2013.12.005. - DOI - PubMed
    1. Menezes M., Tareen F., Saeed A., Khan N., Puri P. Symptomatic Meckel’s diverticulum in children: A 16-year review. Pediatr. Surg. Int. 2008;24:575–577. doi: 10.1007/s00383-007-2094-4. - DOI - PubMed
    1. Gandy B.J., Byrne P., Lees G. Neonatal Meckel’s diverticular inflammation with perforation. J. Pediatr. Surg. 1997;32:750–751. doi: 10.1016/S0022-3468(97)90024-5. - DOI - PubMed
    1. Hansen C.C., Søreide K. Systematic review of epidemiology, presentation, and management of Meckel’s diverticulum in the 21st century. Medicine. 2018;97:e12154. doi: 10.1097/MD.0000000000012154. - DOI - PMC - PubMed
    1. Zani A., Eaton S., Rees C.M., Pierro A. Incidentally detected meckel diverticulum: To resect or not to resect? Ann. Surg. 2008;247:276–281. doi: 10.1097/SLA.0b013e31815aaaf8. - DOI - PubMed