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. 2021 Dec 23;12(1):8.
doi: 10.3390/brainsci12010008.

Cooperative Parent-Mediated Therapy in Children with Fragile X Syndrome and Williams Beuren Syndrome: A Pilot RCT Study of a Transdiagnostic Intervention-Preliminary Data

Paolo Alfieri  1 , Francesco Scibelli  1 , Laura Casula  1 , Simone Piga  2 , Eleonora Napoli  1 , Giovanni Valeri  1 , Stefano Vicari  1   3
Affiliations

Cooperative Parent-Mediated Therapy in Children with Fragile X Syndrome and Williams Beuren Syndrome: A Pilot RCT Study of a Transdiagnostic Intervention-Preliminary Data

Paolo Alfieri et al. Brain Sci. .

Abstract

Children with fragile X syndrome and William Beuren syndrome share several socio-communicative deficits. In both populations, around 30/35% of individuals meets criteria for autism spectrum disorder on gold standard instruments. Notwithstanding, few studies have explored feasibility and validity of therapy for socio-communicative deficits in individuals with these genetic conditions. In this study, we present preliminary data on a pilot RCT aimed to verify the effectiveness of cooperative parent-mediated therapy for socio-communicative deficits in a transdiagnostic perspective in a small sample of 12 participants. Our preliminary data showed that the experimental group had significant improvement in one socio-communicative skill (responsivity) and in clinical global impression, while the control group in an adaptive measure of socialization and word production. Implications of these results are then discussed.

Keywords: RCT; William Beuren syndrome; autism spectrum disorders; fragile X syndrome; parent-mediated therapy; transdiagnostic intervention.

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Conflict of interest statement

The authors declare no conflict of interest.

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