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Review
. 2022 Jan 6;23(2):624.
doi: 10.3390/ijms23020624.

Patient-Specific iPSCs-Based Models of Neurodegenerative Diseases: Focus on Aberrant Calcium Signaling

Dmitriy A Grekhnev  1 , Elena V Kaznacheyeva  1 , Vladimir A Vigont  1
Affiliations
Review

Patient-Specific iPSCs-Based Models of Neurodegenerative Diseases: Focus on Aberrant Calcium Signaling

Dmitriy A Grekhnev et al. Int J Mol Sci. .

Abstract

The development of cell reprogramming technologies became a breakthrough in the creation of new models of human diseases, including neurodegenerative pathologies. The iPSCs-based models allow for the studying of both hereditary and sporadic cases of pathologies and produce deep insight into the molecular mechanisms underlying neurodegeneration. The use of the cells most vulnerable to a particular pathology makes it possible to identify specific pathological mechanisms and greatly facilitates the task of selecting the most effective drugs. To date, a large number of studies on patient-specific models of neurodegenerative diseases has been accumulated. In this review, we focused on the alterations of such a ubiquitous and important intracellular regulatory pathway as calcium signaling. Here, we reviewed and analyzed the data obtained from iPSCs-based models of different neurodegenerative disorders that demonstrated aberrant calcium signaling.

Keywords: Alzheimer’s disease; Huntington’s disease; Parkinson’s disease; amyotrophic lateral sclerosis; calcium signaling; iPSCs; induced pluripotent stem cells; neurodegeneration; patient-specific models; spinocerebellar ataxia.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
iPSCs in modeling neurodegenerative diseases, drug screening, and cell therapy.
See this image and copyright information in PMC

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