Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jan 12;12(2):238.
doi: 10.3390/nano12020238.

Precision and Advanced Nano-Phytopharmaceuticals for Therapeutic Applications

Chooi Ling Lim  1 , Chandramathi S Raju  2 , Tooba Mahboob  2 , Sunil Kayesth  3 , Kamal K Gupta  3 , Gaurav Kumar Jain  4 , Mahaveer Dhobi  4 , Muhammad Nawaz  5 , Polrat Wilairatana  6 , Maria de Lourdes Pereira  7 , Jayanta Kumar Patra  8 , Alok K Paul  9 , Mohammed Rahmatullah  10 , Veeranoot Nissapatorn  11
Affiliations
Review

Precision and Advanced Nano-Phytopharmaceuticals for Therapeutic Applications

Chooi Ling Lim et al. Nanomaterials (Basel). .

Abstract

Phytopharmaceuticals have been widely used globally since ancient times and acknowledged by healthcare professionals and patients for their superior therapeutic value and fewer side-effects compared to modern medicines. However, phytopharmaceuticals need a scientific and methodical approach to deliver their components and thereby improve patient compliance and treatment adherence. Dose reduction, improved bioavailability, receptor selective binding, and targeted delivery of phytopharmaceuticals can be likely achieved by molding them into specific nano-formulations. In recent decades, nanotechnology-based phytopharmaceuticals have emerged as potential therapeutic candidates for the treatment of various communicable and non-communicable diseases. Nanotechnology combined with phytopharmaceuticals broadens the therapeutic perspective and overcomes problems associated with plant medicine. The current review highlights the therapeutic application of various nano-phytopharmaceuticals in neurological, cardiovascular, pulmonary, and gastro-intestinal disorders. We conclude that nano-phytopharmaceuticals emerge as promising therapeutics for many pathological conditions with good compliance and higher acceptance.

Keywords: herbal medications; nano-formulations; phytopharmaceuticals; precision; therapeutics.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Representation of delivery of phytopharmaceuticals using nanotechnology. The figure was made with www.biorender.com (access date: 17 December 2021).
Figure 2
Figure 2
Encapsulation of bioactive compounds from herbal extracts of Curcuma longa and Panax ginseng into various nanoparticle platforms facilitates delivery to targeted areas in the brain from the blood, improves solubility, and enhances retention rates. The figure was made with www.biorender.com (access date: 12 January 2022). Abbreviations: BBB, blood-brain barrier; PLGA, poly (d,l-lactic acid-co-glycolic acid).
Figure 3
Figure 3
Encapsulation of bioactive compounds with nanoparticles from various herbal extracts to prevent cardiovascular disorders. Abbreviation: PLGA, poly (d,l-lactic acid-co-glycolic acid). The figure was made with www.biorender.com (access date: 12 January 2022).
Figure 4
Figure 4
Encapsulation of bio-active compounds from various herbal extracts with silver, silicon, or gold nanoparticles to improve delivery in lungs and to prevent pulmonary disorders. The figure was made with www.biorender.com (access date: 12 January 2022).
Figure 5
Figure 5
Encapsulation of bioactive compounds from various herbal extracts with silver, gold, cellulose, and polymeric nanoparticles to improve delivery in the gastrointestinal tract, and to prevent or cure various diseases. The figure was made with www.biorender.com (access date: 12 January 2022).
See this image and copyright information in PMC

References

    1. Mobasser S., Firoozi A.A. Review of nanotechnology applications in science and engineering. J. Civil. Eng. Urban. 2017;64:84–93.
    1. Chen G., Roy I., Yang C., Prasad P.N. Nanochemistry and nanomedicine for nanoparticle-based diagnostics and therapy. Chem. Rev. 2016;116:2826–2885. doi: 10.1021/acs.chemrev.5b00148. - DOI - PubMed
    1. Morelli L., Gimondi S., Sevieri M., Salvioni L., Guizzetti M., Colzani B., Palugan L., Foppoli A., Talamini L., Morosi L., et al. Monitoring the fate of orally administered PLGA nanoformulation for local delivery of therapeutic drugs. Pharmaceutics. 2019;11:658. doi: 10.3390/pharmaceutics11120658. - DOI - PMC - PubMed
    1. Zhao Q., Luan X., Zheng M., Tian X.-H., Zhao J., Zhang W.-D., Ma B.-L. Synergistic mechanisms of constituents in herbal extracts during intestinal absorption: Focus on natural occurring nanoparticles. Pharmaceutics. 2020;12:128. doi: 10.3390/pharmaceutics12020128. - DOI - PMC - PubMed
    1. Kumari P., Luqman S., Meena A. Application of the combinatorial approaches of medicinal and aromatic plants with nanotechnology and its impacts on healthcare. DARU J. Pharm. Sci. 2019;27:475–489. doi: 10.1007/s40199-019-00271-6. - DOI - PMC - PubMed

LinkOut - more resources