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Review
. 2021 Dec 21;12(1):3.
doi: 10.3390/jpm12010003.

Building a Personalized Medicine Infrastructure for Gynecological Oncology Patients in a High-Volume Hospital

Nicolò Bizzarri  1 , Camilla Nero  1   2   3 , Francesca Sillano  1 , Francesca Ciccarone  1   3 , Marika D'Oria  3 , Alfredo Cesario  3 , Simona Maria Fragomeni  1 , Antonia Carla Testa  1   2 , Francesco Fanfani  1   2 , Gabriella Ferrandina  1   2 , Domenica Lorusso  1   2   3 , Anna Fagotti  1   2 , Giovanni Scambia  1   2   3
Affiliations
Review

Building a Personalized Medicine Infrastructure for Gynecological Oncology Patients in a High-Volume Hospital

Nicolò Bizzarri et al. J Pers Med. .

Abstract

Gynecological cancers require complex intervention since patients have specific needs to be addressed. Centralization to high-volume centers improves the oncological outcomes of patients with gynecological cancers. Research in gynecological oncology is increasing thanks to modern technologies, from the comprehensive molecular characterization of tumors and individual pathophenotypes. Ongoing studies are focusing on personalizing therapies by integrating information across genomics, proteomics, and metabolomics with the genetic makeup and immune system of the patient. Hence, several challenges must be faced to provide holistic benefit to the patient. Personalized approaches should also recognize the unmet needs of each patient to successfully deliver the promise of personalized care, in a multidisciplinary effort. This may provide the greatest opportunity to improve patients' outcomes. Starting from a narrative review on gynecological oncology patients' needs, this article focuses on the experience of building a research and care infrastructure for personalized patient management.

Keywords: gynecologic oncology; patient-centered care; personalized medicine.

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Conflict of interest statement

All authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Abraham Maslow’s pyramid on the five human needs, with the most basic at the bottom.
Figure 2
Figure 2
Hall (a) and interior (b) view of the emergency admission service for patients with suspected or diagnosed gynecological cancer.
Figure 3
Figure 3
(a,b) Interior view of CLASS Ultrasound.
Figure 4
Figure 4
A glimpse into the rooms of CLASS Hysteroscopy.
Figure 5
Figure 5
Interior (a) and exterior (b) view of the therapeutic garden.
Figure 6
Figure 6
Map of the hospital campus (a) and external view of the hotel (b). The blue pin in figure (a) indicates the hotel location within the hospital campus (whose area is represented in color).
Figure 7
Figure 7
Research facilities of the Gemelli Science and Technology Park. A short virtual tour of the G-STeP can be taken at: https://gstep.policlinicogemelli.it/#/ChiSiamo (accessed on 9 October 2021).
See this image and copyright information in PMC

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