Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jan 3;12(1):35.
doi: 10.3390/jpm12010035.

Advances of Genomic Medicine in Psoriatic Arthritis

Carlos M Laborde  1 , Leyre Larzabal  1 , Álvaro González-Cantero  2   3 , Patricia Castro-Santos  4 , Roberto Díaz-Peña  5
Affiliations
Review

Advances of Genomic Medicine in Psoriatic Arthritis

Carlos M Laborde et al. J Pers Med. .

Abstract

Psoriatic arthritis (PsA) is a common type of inflammatory arthritis found in up to 40% of patients with psoriasis. Although early diagnosis is important for reducing the risk of irreversible structural damage, there are no adequate screening tools for this purpose, and there are no clear markers of predisposition to the disease. Much evidence indicates that PsA disorder is complex and heterogeneous, where genetic and environmental factors converge to trigger inflammatory events and the development of the disease. Nevertheless, the etiologic events that underlie PsA are complex and not completely understood. In this review, we describe the existing data in PsA in order to highlight the need for further research in this disease to progress in the knowledge of its pathobiology and to obtain early diagnosis tools for these patients.

Keywords: epigenomics; genome-wide association studies; genomics; personalized medicine; psoriatic arthritis; spondyloarthropathies; transcriptomics.

PubMed Disclaimer

Conflict of interest statement

Carlos M. Laborde and Leyre Larzabal are currently employees of Dreamgenics, Inc. The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Shared non-human leukocyte antigen susceptibility genes between psoriatic arthritis and other diseases. Abbreviations: AS, ankylosing spondylitis; IBD, inflammatory bowel disease; PsA, psoriatic arthritis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus.
See this image and copyright information in PMC

References

    1. Van den Bosch F., Coates L. Clinical Management of Psoriatic Arthritis. Lancet. 2018;391:2285–2294. doi: 10.1016/S0140-6736(18)30949-8. - DOI - PubMed
    1. Moll J.M., Wright V. Psoriatic Arthritis. Semin. Arthritis Rheum. 1973;3:55–78. doi: 10.1016/0049-0172(73)90035-8. - DOI - PubMed
    1. Taylor W., Gladman D., Helliwell P., Marchesoni A., Mease P., Mielants H. CASPAR Study Group Classification Criteria for Psoriatic Arthritis: Development of New Criteria from a Large International Study. Arthritis Rheum. 2006;54:2665–2673. doi: 10.1002/art.21972. - DOI - PubMed
    1. Alinaghi F., Calov M., Kristensen L.E., Gladman D.D., Coates L.C., Jullien D., Gottlieb A.B., Gisondi P., Wu J.J., Thyssen J.P., et al. Prevalence of Psoriatic Arthritis in Patients with Psoriasis: A Systematic Review and Meta-Analysis of Observational and Clinical Studies. J. Am. Acad. Derm. 2019;80:251.e19–265.e19. doi: 10.1016/j.jaad.2018.06.027. - DOI - PubMed
    1. Myers W.A., Gottlieb A.B., Mease P. Psoriasis and Psoriatic Arthritis: Clinical Features and Disease Mechanisms. Clin. Derm. 2006;24:438–447. doi: 10.1016/j.clindermatol.2006.07.006. - DOI - PubMed