Metabolic Obesity in People with Normal Body Weight (MONW)-Review of Diagnostic Criteria

Abstract

Disorders of metabolic obesity with normal body weight (MONW) are widely recognized risk factors for the development of cardiovascular diseases and type 2 diabetes. Despite this, MONW is not diagnosed in clinical practice. There is no consensus on the definition of MONW, and measuring the degree of insulin resistance or obesity among apparently healthy, non-obese patients is not widely applicable. The awareness of the relationship between metabolic disorders such as MONW and a higher risk of mortality from cardiovascular causes and other related diseases prompts the need for action to be taken aimed at creating appropriate diagnostic models that will allow for the effective detection of those with metabolic abnormalities among people with normal body weight. Such actions are decisive in the prevention and treatment of diseases. Therefore, the purpose of this article is to review the MONW diagnostic criteria used over the years.

Keywords: MONW; diagnostic criteria; obesity.

Figure 1

The effects of abdominal obesity and insulin resistance [13,14,15,16,17,18,19,20,21,22,23,24,25,26]. Legend: VLDL—very-low-density lipoprotein, NO—nitric oxide, PAI-1—plasminogen activator inhibitor-1, t-PA—tissue plasminogen activator, ATIII—antithrombin III, NF-κB—Il-8—interleukin-8, TNF-α—tumor necrosis factor α, β-HSD—beta- hydroxysteroid dehydrogenase, PPAR-γ—peroxisome proliferator-activated receptor gamma, HDL—high-density lipoprotein, LDL—low-density lipoprotein.