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. 2022 Jan 14;19(2):931.
doi: 10.3390/ijerph19020931.

Lipoprotein Profile in Populations from Regions of the Russian Federation: ESSE-RF Study

Victoria A Metelskaya  1 , Svetlana A Shalnova  1 , Elena B Yarovaya  1   2 , Vladimir A Kutsenko  1   2 , Sergey A Boytsov  3 , Eugeny V Shlyakhto  4 , Oxana M Drapkina  1
Affiliations

Lipoprotein Profile in Populations from Regions of the Russian Federation: ESSE-RF Study

Victoria A Metelskaya et al. Int J Environ Res Public Health. .

Abstract

This study aimed to describe the dyslipidemia prevalence and pattern among adult populations from different regions (n = 13) of the Russian Federation (RF). Randomly selected samples (n = 22,258, aged 25-64) were studied according to the ESSE-RF protocol. Lipoprotein parameters were estimated by routine methods. Statistical analyses were performed using R software (v.3.5.1). The overall dyslipidemia prevalence was 76.1% (76.9/75.3% for men/women). In women, total cholesterol (TC) and low-density lipoprotein (LDL)-C levels gradually increased with age (from 4.72 to 5.93 and from 2.76 to 3.79 mmol/L, respectively); in men, they reached a maximum by 45-54 (5.55 and 3.55 mmol/L, respectively) and then decreased. No differences in high-density lipoprotein (HDL)-C in men of different ages were found, but slight decreases in HDL-C and apo AI were observed in women by 55-64 years. No pronounced associations between education and lipid levels in men were observed; higher-educated women showed significantly better lipoprotein profiles. Similar associations between lipids and income level were detected. Women from rural areas had higher TC and triglycerides than urban residents. Regardless of sex, rural residents had higher HDL-C and apo AI, and reduced apo B/apo AI. Conclusion: Information on the peculiarities of dyslipidemia prevalence and lipoprotein profile depending on sex, age, residential place, and socioeconomic status is useful for assessing the global ASCVD risk, and for risk modeling based on national data.

Keywords: ESSE-RF; dyslipidemia; lipoprotein profile; population-based study; prevalence; socioeconomic status.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Dyslipidemia prevalence according to ESSE-RF study data. (*) indicates the significant difference between men and women in the corresponding age group.
Figure 2
Figure 2
Sex- and age-specific levels of: (A) total cholesterol; (B) LDL-C; (C) Triglycerides; (D) HDL-C; (E) apoB/ apo AI; (F) Lp(a). (*) indicates the significant difference between men and women in the corresponding age group.
See this image and copyright information in PMC

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