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Case Reports
. 2021 Dec 27;58(1):37.
doi: 10.3390/medicina58010037.

De Novo Minimal Change Disease following Vaccination with the Pfizer/BioNTech SARS-CoV-2 Vaccine in a Living Kidney Donor

Smaragdi Marinaki  1 , Kyriaki Kolovou  1 , George Liapis  2 , Chrysanthi Skalioti  1 , Stathis Tsiakas  1 , Ioannis Boletis  1
Affiliations
Case Reports

De Novo Minimal Change Disease following Vaccination with the Pfizer/BioNTech SARS-CoV-2 Vaccine in a Living Kidney Donor

Smaragdi Marinaki et al. Medicina (Kaunas). .

Abstract

Coronavirus disease 2019 has developed as a pandemic. Immunization with the introduction of vaccines against COVID-19 seems be the only way to end this pandemic. We report on a case of a kidney donor, who developed minimal change disease (MCD) within 4 days post-vaccination with the SARS-CoV-2 BNT162b2 mRNA vaccine (Pfizer/BioNTech). She donated her kidney to her husband 4 years ago. After receiving the 1st vaccine dose, she presented with nephrotic syndrome, with complete remission 5 days later. She proceeded with the second dose of the BNT162b2 vaccine at the appointed time. Two days later, she presented with a relapse of full-blown nephrotic syndrome with preserved renal function. We performed an ultrasound-guided percutaneous kidney biopsy and the final diagnosis was consistent with minimal change disease. Oral prednisolone was promptly initiated at a dosage of 1 mg/kg daily and complete remission was achieved 10 days later. More data about this rare appearance of de novo glomerular diseases after SARS-CoV-2 vaccination are emerging and should be interpreted rigorously.

Keywords: COVID-19 vaccination; SARS-CoV-2 mRNA vaccines; de novo glomerulonephritis; kidney donor; minimal change disease.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Laboratory data.
Figure 2
Figure 2
Images from light microscope (a), electron microscope (b).
See this image and copyright information in PMC

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