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. 2022 Jan 7;10(1):125.
doi: 10.3390/microorganisms10010125.

Antimicrobial Susceptibility of Clinical Oral Isolates of Actinomyces spp

Alexandra Wolff  1 , Arne C Rodloff  1 , Paul Vielkind  1 , Toralf Borgmann  1 , Catalina-Suzana Stingu  1
Affiliations

Antimicrobial Susceptibility of Clinical Oral Isolates of Actinomyces spp

Alexandra Wolff et al. Microorganisms. .

Abstract

Actinomyces species play an important role in the pathogenesis of oral diseases and infections. Susceptibility testing is not always routinely performed, and one may oversee a shift in resistance patterns. The aim of the study was to analyze the antimicrobial susceptibility of 100 well-identified clinical oral isolates of Actinomyces spp. against eight selected antimicrobial agents using the agar dilution (AD) and E-Test (ET) methods. We observed no to low resistance against penicillin, ampicillin-sulbactam, meropenem, clindamycin, linezolid and tigecycline (0-2% ET, 0% AD) but high levels of resistance to moxifloxacin (93% ET, 87% AD) and daptomycin (83% ET, 95% AD). The essential agreement of the two methods was very good for benzylpenicillin (EA 95%) and meropenem (EA 92%). The ET method was reliable for correctly categorizing susceptibility, in comparison with the reference method agar dilution, except for daptomycin (categorical agreement 87%). Penicillin is still the first-choice antibiotic for therapy of diseases caused by Actinomyces spp.

Keywords: Actinomyces; E-Test; agar dilution; susceptibility testing.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Vielkind P., Jentsch H., Eschrich K., Rodloff A.C., Stingu C.-S. Prevalence of Actinomyces spp. in patients with chronic periodontitis. Int. J. Med. Microbiol. 2015;305:682–688. doi: 10.1016/j.ijmm.2015.08.018. - DOI - PubMed
    1. Marsh P., Martin M.V. Orale Mikrobiologie: 60 Tabellen. Thieme; Stuttgart, Germany: 2003.
    1. Palmer R.J., Gordon S.M., Cisar J.O., Kolenbrander P.E. Coaggregation-Mediated Interactions of Streptococci and Actinomyces Detected in Initial Human Dental Plaque. J. Bacteriol. 2003;185:3400–3409. doi: 10.1128/JB.185.11.3400-3409.2003. - DOI - PMC - PubMed
    1. Cavalcanti I., Del Bel Cury A.A., Jenkinson H.F., Nobbs A.H. Interactions between Streptococcus oralis, Actinomyces oris, and Candida albicans in the development of multispecies oral microbial biofilms on salivary pellicle. Moloral. Microbiol. 2017;32:60–73. doi: 10.1111/omi.12154. - DOI - PubMed
    1. Zelyas N., Gee S., Nilsson B., Bennett T., Rennie R. Infections Caused by Actinomyces neuii: A Case Series and Review of an Unusual Bacterium. Can. J. Infect. Dis. Med. Microbiol. 2016;2016:6017605. doi: 10.1155/2016/6017605. - DOI - PMC - PubMed

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