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Review
. 2022 Jan 15;14(1):202.
doi: 10.3390/pharmaceutics14010202.

Mesoporous Bioglasses Enriched with Bioactive Agents for Bone Repair, with a Special Highlight of María Vallet-Regí's Contribution

Antonio J Salinas  1   2 , Pedro Esbrit  1
Affiliations
Review

Mesoporous Bioglasses Enriched with Bioactive Agents for Bone Repair, with a Special Highlight of María Vallet-Regí's Contribution

Antonio J Salinas et al. Pharmaceutics. .

Abstract

Throughout her impressive scientific career, Prof. María Vallet-Regí opened various research lines aimed at designing new bioceramics, including mesoporous bioactive glasses for bone tissue engineering applications. These bioactive glasses can be considered a spin-off of silica mesoporous materials because they are designed with a similar technical approach. Mesoporous glasses in addition to SiO2 contain significant amounts of other oxides, particularly CaO and P2O5 and therefore, they exhibit quite different properties and clinical applications than mesoporous silica compounds. Both materials exhibit ordered mesoporous structures with a very narrow pore size distribution that are achieved by using surfactants during their synthesis. The characteristics of mesoporous glasses made them suitable to be enriched with various osteogenic agents, namely inorganic ions and biopeptides as well as mesenchymal cells. In the present review, we summarize the evolution of mesoporous bioactive glasses research for bone repair, with a special highlight on the impact of Prof. María Vallet-Regí´s contribution to the field.

Keywords: Prof. Vallet-Regí: regenerative medicine; bioactive biomolecules; bone repair; mesoporous bioactive glasses; stem cells; therapeutical ions.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Main features of: (A) glasses and (B) the three families of bioactive glasses.
Figure 2
Figure 2
Textural properties of the three families of bioactive glasses. Transmission Electron Micrographs of the porous SGG and MBG are also included.
Figure 3
Figure 3
Main properties of the three families of BGs for bone regeneration applications.
Figure 4
Figure 4
Members of the Vallet-Regí group and external collaborations in the field of MBGs.
Figure 5
Figure 5
MBGs tree after María Vallet-Regí.
See this image and copyright information in PMC

References

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