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Meta-Analysis
. 2022 Jan 14;14(2):342.
doi: 10.3390/nu14020342.

The Impact of Selenium Supplementation on Trauma Patients-Systematic Review and Meta-Analysis

Jen-Fu Huang  1 , Chih-Po Hsu  1 , Chun-Hsiang Ouyang  1 , Chi-Tung Cheng  1 , Chia-Cheng Wang  1 , Chien-Hung Liao  1 , Yu-Tung Wu  1 , Chi-Hsun Hsieh  1
Affiliations
Meta-Analysis

The Impact of Selenium Supplementation on Trauma Patients-Systematic Review and Meta-Analysis

Jen-Fu Huang et al. Nutrients. .

Abstract

This study aimed to assess current evidence regarding the effect of selenium (Se) supplementation on the prognosis in patients sustaining trauma. MEDLINE, Embase, and Web of Science databases were searched with the following terms: "trace element", "selenium", "copper", "zinc", "injury", and "trauma". Seven studies were included in the meta-analysis. The pooled results showed that Se supplementation was associated with a lower mortality rate (OR 0.733, 95% CI: 0.586, 0.918, p = 0.007; heterogeneity, I2 = 0%). Regarding the incidence of infectious complications, there was no statistically significant benefit after analyzing the four studies (OR 0.942, 95% CI: 0.695, 1.277, p = 0.702; heterogeneity, I2 = 14.343%). The patients with Se supplementation had a reduced ICU length of stay (standard difference in means (SMD): -0.324, 95% CI: -0.382, -0.265, p < 0.001; heterogeneity, I2 = 0%) and lesser hospital length of stay (SMD: -0.243, 95% CI: -0.474, -0.012, p < 0.001; heterogeneity, I2 = 45.496%). Se supplementation after trauma confers positive effects in decreasing the mortality and length of ICU and hospital stay.

Keywords: injury; selenium; trace element; trauma.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Protocol of this systematic review.
Figure 2
Figure 2
Forest chart of selenium (Se) supplementation on mortality of severe trauma patients.
Figure 3
Figure 3
Forest chart of selenium (Se) supplementation on infection occurrence in severe trauma patients.
Figure 4
Figure 4
Forest chart of selenium (Se) supplementation on the length of intensive care unit stay of severe trauma patients.
Figure 5
Figure 5
Forest chart of selenium (Se) supplementation on the length of hospital stay of severe trauma patients.
See this image and copyright information in PMC

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