. 2022 Jan 20;12(1):e048166.

doi: 10.1136/bmjopen-2020-048166.

Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity

Kylie E Hunter¹, Brittany J Johnson², Lisa Askie³, Rebecca K Golley², Louise A Baur⁴, Ian C Marschner³, Rachael W Taylor⁵, Luke Wolfenden⁶, Charles T Wood⁷, Seema Mihrshahi⁸, Alison J Hayes⁹, Chris Rissel⁹, Kristy P Robledo³, Denise A O'Connor^{10

11}, David Espinoza³, Lukas P Staub³, Paul Chadwick¹², Sarah Taki^{9

13}, Angie Barba³, Sol Libesman³, Mason Aberoumand³, Wendy A Smith^{14

15}, Michelle Sue-See¹⁵, Kylie D Hesketh¹⁶, Jessica L Thomson¹⁷, Maria Bryant¹⁸, Ian M Paul¹⁹, Vera Verbestel²⁰, Cathleen Odar Stough²¹, Li Ming Wen^{9

13}, Junilla K Larsen²², Sharleen L O'Reilly²³, Heather M Wasser²⁴, Jennifer S Savage²⁵, Ken K Ong²⁶, Sarah-Jeanne Salvy²⁷, Mary Jo Messito²⁸, Rachel S Gross²⁸, Levie T Karssen²², Finn E Rasmussen²⁹, Karen Campbell¹⁶, Ana Maria Linares³⁰, Nina Cecilie Øverby³¹, Cristina Palacios³², Kaumudi J Joshipura^{33

34}, Carolina González Acero³⁵, Rajalakshmi Lakshman²⁶, Amanda L Thompson^{24

36}, Claudio Maffeis³⁷, Emily Oken³⁸, Ata Ghaderi³⁹, Maribel Campos Rivera⁴⁰, Ana B Pérez-Expósito⁴¹, Jinan C Banna⁴², Kayla de la Haye⁴³, Michael Goran⁴³, Margrethe Røed³¹, Stephanie Anzman-Frasca⁴⁴, Barry J Taylor⁴⁵, Anna Lene Seidler³; Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration

Collaborators, Affiliations

Collaborators

Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration:
Anna Lene Seidler, Kylie Hunter, Brittany Johnson, Rebecca Golley, Angie Barba, Lisa Askie, Mason Aberoumand, Sol Libesman, Jonathan Williams, Louise Baur, Paul Chadwick, David Espinoza, Alison Hayes, Ian Marschner, Seema Mihrshahi, Denise O'Connor, Chris Rissel, Kristy Robledo, Lee Sanders, Wendy Smith, Lukas Staub, Michelle Sue-See, Sarah Taki, Rachael Taylor, Angela Webster, Luke Wolfenden, Charles Wood, Shonna Yin, Stephanie Anzman-Frasca, Jinan Banna, Maria Bryant, Rebecca Byrne, Karen Campbell, Maribel Campos Rivera, Eva Corpeleijn, Lynne Daniels, Cindy-Lee Dennis, Kayla Dela Haye, Alexander Fiks, Ata Ghaderi, Carolina González Acero, Michael Goran, Rachel Gross, Christine Helle, Kylie Hesketh, Deborah Jacobvitz, Kaumudi Joshipura, Alison Karasz, Levie Karssen, Rajalakshmi Lakshman, Junilla K Larsen, Ana Maria Linares, Claudio Maffeis, Mary Jo Messito, Emily Oken, Ken Ong, Sharleen O'Reilly, Nina Øverby, Cristina Palacios, Ian M Paul, Ana Perez-Exposito, Eliana Perrin, Hein Raat, Finn Rasmussen, Margrethe Røed, Russell Rothman, Sarah-Jeanne Salvy, Jennifer Savage Williams, Cathleen Odar Stough, Barry Taylor, Rachael Taylor, Amanda Thompson, Jessica Thomson, Vera Verbestel, Márcia Regina Vitolo, Heather Wasser, Li Ming Wen, Elizabeth Widen, Hongping Xia

Affiliations

¹ NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia kylie.hunter@sydney.edu.au.
² Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia.
³ NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
⁴ Children's Hospital Westmead Clinical School, The University of Sydney, Westmead, New South Wales, Australia.
⁵ Department of Medicine, University of Otago, Dunedin, New Zealand.
⁶ School of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia.
⁷ School of Medicine, Duke University, Durham, North Carolina, USA.
⁸ Department of Health Systems and Populations, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
⁹ School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
¹⁰ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.
¹¹ Monash Department of Clinical Epidemiology, Cabrini Institute, Malvern, Victoria, Australia.
¹² Centre For Behaviour Change, University College London, London, UK.
¹³ Population Health Research and Evaluation Hub, Sydney Local Health District, Camperdown, New South Wales, Australia.
¹⁴ Canterbury Community Health Centre, Sydney Local Health District, Campsie, New South Wales, Australia.
¹⁵ Consumer Representative, Sydney, New South Wales, Australia.
¹⁶ Institute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia.
¹⁷ Agricultural Research Service, USDA, Stoneville, Mississippi, USA.
¹⁸ Department of Health Sciences and the Hull York Medical School, University of York, York, UK.
¹⁹ Penn State College of Medicine, Hershey, Pennsylvania, USA.
²⁰ Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium.
²¹ Department of Psychology, University of Cincinnati, Cincinnati, Ohio, USA.
²² Behavioural Science Institute, Radboud Universiteit, Nijmegen, The Netherlands.
²³ School of Agriculture and Food Science, University College Dublin, Dublin, Ireland.
²⁴ Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
²⁵ Department of Nutritional Sciences & Center for Childhood Obesity Research, Pennsylvania State University, University Park, Pennsylvania, USA.
²⁶ MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
²⁷ Research Center for Health Equity, Cedars-Sinai Medical Center, West Hollywood, California, USA.
²⁸ Grossman School of Medicine, New York University, New York, New York, USA.
²⁹ Department of Global Public Health, Karolinska Institute, Stockholm, Sweden.
³⁰ College of Nursing, University of Kentucky, Lexington, Kentucky, USA.
³¹ Faculty of Health and Sport Sciences, Department of Nutrition and Public Health, University of Agder, Kristiansand, Vest-Agder, Norway.
³² Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, Florida, USA.
³³ Department of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
³⁴ Center for Clinical Research and Health Promotion, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, USA.
³⁵ Social Protection and Health Division, Inter-American Development Bank, Santo Domingo, Distrito Nacional, Dominican Republic.
³⁶ Department of Anthropology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
³⁷ Pediatric Diabetes and Metabolic Disorders Unit, University of Verona, Verona, Italy.
³⁸ Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
³⁹ Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
⁴⁰ Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico, USA.
⁴¹ Social Protection and Health Division, Inter-American Development Bank, Washington, District of Columbia, USA.
⁴² Department of Human Nutrition, Food and Animal Sciences, University of Hawaii, Honolulu, Hawaii, USA.
⁴³ Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA.
⁴⁴ Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
⁴⁵ Better Start National Science Challenge, University of Otago, Dunedin, New Zealand.

PMID: 35058256
PMCID: PMC8783820
DOI: 10.1136/bmjopen-2020-048166

Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity

Kylie E Hunter et al. BMJ Open. 2022.

. 2022 Jan 20;12(1):e048166.

doi: 10.1136/bmjopen-2020-048166.

Authors

Collaborators

Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration:
Anna Lene Seidler, Kylie Hunter, Brittany Johnson, Rebecca Golley, Angie Barba, Lisa Askie, Mason Aberoumand, Sol Libesman, Jonathan Williams, Louise Baur, Paul Chadwick, David Espinoza, Alison Hayes, Ian Marschner, Seema Mihrshahi, Denise O'Connor, Chris Rissel, Kristy Robledo, Lee Sanders, Wendy Smith, Lukas Staub, Michelle Sue-See, Sarah Taki, Rachael Taylor, Angela Webster, Luke Wolfenden, Charles Wood, Shonna Yin, Stephanie Anzman-Frasca, Jinan Banna, Maria Bryant, Rebecca Byrne, Karen Campbell, Maribel Campos Rivera, Eva Corpeleijn, Lynne Daniels, Cindy-Lee Dennis, Kayla Dela Haye, Alexander Fiks, Ata Ghaderi, Carolina González Acero, Michael Goran, Rachel Gross, Christine Helle, Kylie Hesketh, Deborah Jacobvitz, Kaumudi Joshipura, Alison Karasz, Levie Karssen, Rajalakshmi Lakshman, Junilla K Larsen, Ana Maria Linares, Claudio Maffeis, Mary Jo Messito, Emily Oken, Ken Ong, Sharleen O'Reilly, Nina Øverby, Cristina Palacios, Ian M Paul, Ana Perez-Exposito, Eliana Perrin, Hein Raat, Finn Rasmussen, Margrethe Røed, Russell Rothman, Sarah-Jeanne Salvy, Jennifer Savage Williams, Cathleen Odar Stough, Barry Taylor, Rachael Taylor, Amanda Thompson, Jessica Thomson, Vera Verbestel, Márcia Regina Vitolo, Heather Wasser, Li Ming Wen, Elizabeth Widen, Hongping Xia

Affiliations

¹ NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia kylie.hunter@sydney.edu.au.
² Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia.
³ NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
⁴ Children's Hospital Westmead Clinical School, The University of Sydney, Westmead, New South Wales, Australia.
⁵ Department of Medicine, University of Otago, Dunedin, New Zealand.
⁶ School of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia.
⁷ School of Medicine, Duke University, Durham, North Carolina, USA.
⁸ Department of Health Systems and Populations, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
⁹ School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
¹⁰ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.
¹¹ Monash Department of Clinical Epidemiology, Cabrini Institute, Malvern, Victoria, Australia.
¹² Centre For Behaviour Change, University College London, London, UK.
¹³ Population Health Research and Evaluation Hub, Sydney Local Health District, Camperdown, New South Wales, Australia.
¹⁴ Canterbury Community Health Centre, Sydney Local Health District, Campsie, New South Wales, Australia.
¹⁵ Consumer Representative, Sydney, New South Wales, Australia.
¹⁶ Institute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia.
¹⁷ Agricultural Research Service, USDA, Stoneville, Mississippi, USA.
¹⁸ Department of Health Sciences and the Hull York Medical School, University of York, York, UK.
¹⁹ Penn State College of Medicine, Hershey, Pennsylvania, USA.
²⁰ Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium.
²¹ Department of Psychology, University of Cincinnati, Cincinnati, Ohio, USA.
²² Behavioural Science Institute, Radboud Universiteit, Nijmegen, The Netherlands.
²³ School of Agriculture and Food Science, University College Dublin, Dublin, Ireland.
²⁴ Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
²⁵ Department of Nutritional Sciences & Center for Childhood Obesity Research, Pennsylvania State University, University Park, Pennsylvania, USA.
²⁶ MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
²⁷ Research Center for Health Equity, Cedars-Sinai Medical Center, West Hollywood, California, USA.
²⁸ Grossman School of Medicine, New York University, New York, New York, USA.
²⁹ Department of Global Public Health, Karolinska Institute, Stockholm, Sweden.
³⁰ College of Nursing, University of Kentucky, Lexington, Kentucky, USA.
³¹ Faculty of Health and Sport Sciences, Department of Nutrition and Public Health, University of Agder, Kristiansand, Vest-Agder, Norway.
³² Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, Florida, USA.
³³ Department of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
³⁴ Center for Clinical Research and Health Promotion, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, USA.
³⁵ Social Protection and Health Division, Inter-American Development Bank, Santo Domingo, Distrito Nacional, Dominican Republic.
³⁶ Department of Anthropology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
³⁷ Pediatric Diabetes and Metabolic Disorders Unit, University of Verona, Verona, Italy.
³⁸ Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
³⁹ Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
⁴⁰ Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico, USA.
⁴¹ Social Protection and Health Division, Inter-American Development Bank, Washington, District of Columbia, USA.
⁴² Department of Human Nutrition, Food and Animal Sciences, University of Hawaii, Honolulu, Hawaii, USA.
⁴³ Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA.
⁴⁴ Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
⁴⁵ Better Start National Science Challenge, University of Otago, Dunedin, New Zealand.

PMID: 35058256
PMCID: PMC8783820
DOI: 10.1136/bmjopen-2020-048166

Abstract

Introduction: Behavioural interventions in early life appear to show some effect in reducing childhood overweight and obesity. However, uncertainty remains regarding their overall effectiveness, and whether effectiveness differs among key subgroups. These evidence gaps have prompted an increase in very early childhood obesity prevention trials worldwide. Combining the individual participant data (IPD) from these trials will enhance statistical power to determine overall effectiveness and enable examination of individual and trial-level subgroups. We present a protocol for a systematic review with IPD meta-analysis to evaluate the effectiveness of obesity prevention interventions commencing antenatally or in the first year after birth, and to explore whether there are differential effects among key subgroups.

Methods and analysis: Systematic searches of Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycInfo and trial registries for all ongoing and completed randomised controlled trials evaluating behavioural interventions for the prevention of early childhood obesity have been completed up to March 2021 and will be updated annually to include additional trials. Eligible trialists will be asked to share their IPD; if unavailable, aggregate data will be used where possible. An IPD meta-analysis and a nested prospective meta-analysis will be performed using methodologies recommended by the Cochrane Collaboration. The primary outcome will be body mass index z-score at age 24±6 months using WHO Growth Standards, and effect differences will be explored among prespecified individual and trial-level subgroups. Secondary outcomes include other child weight-related measures, infant feeding, dietary intake, physical activity, sedentary behaviours, sleep, parenting measures and adverse events.

Ethics and dissemination: Approved by The University of Sydney Human Research Ethics Committee (2020/273) and Flinders University Social and Behavioural Research Ethics Committee (HREC CIA2133-1). Results will be relevant to clinicians, child health services, researchers, policy-makers and families, and will be disseminated via publications, presentations and media releases.

Prospero registration number: CRD42020177408.

Keywords: community child health; paediatrics; preventive medicine; public health.

PubMed Disclaimer

Conflict of interest statement

Competing interests: AB, ALS, BJJ, KEH, MA, RKG, SL and LPS reports grants from NHMRC Ideas Grant TOPCHILD (Transforming Obesity Prevention for CHILDren) (GNT1186363); APE and CGA reports grants administered by the Inter-American Development Bank from The Government of Japan and The PepsiCo Foundation; ALT reports grants from National Institute of Health; BJT reports grants from NZ Health Research Council; EO reports grants from the US National Institutes of Health, and the Canadian Institutes for Health Research; IMP reports grants from NIH/NIDDK; JSS reports grants from PCORI, NIH NIDDK and NHLBI, and personal fees from Danone Organic, American Academy of Pediatrics, and Lets Move Maine; LTK and JKL reports grants from Fonds NutsOhra; MCR reports grants from National Institute on Minority Health and Health Disparities-National Institutes of Health/Center for Collaborative Research in Health Disparities, and personal fees from Rhythm Pharmaceuticals; RSG reports grants from US Department of Agriculture and NIH/NICHD.

References

1. World Health Organization . Taking action on childhood obesity. Geneva, Switzerland: WHO, 2018.
1. World Health Organization . Report of the Comission on ending childhood obesity. Geneva, Switzerland: WHO, 2016.
1. United Nations Children’s Fund (UNICEF), World Health Organization, International Bank for Reconstruction and Development/The World Bank . Levels and trends in child malnutrition: key findings of the 2020 edition of the joint child malnutrition estimates. Geneva: World Health Organization, 2020.
1. UNICEF . The State of the World’s Children 2019. Children, Food and Nutrition: Growing well in a changing world. New York: UNICEF, 2019.
1. Di Cesare M, Sorić M, Bovet P, et al. . The epidemiological burden of obesity in childhood: a worldwide epidemic requiring urgent action. BMC Med 2019;17:212. 10.1186/s12916-019-1449-8 - DOI - PMC - PubMed

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Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity

Collaborators

Affiliations

Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical