Comparing Plasma Donor-Derived Cell-free DNA to Indication Kidney Biopsy Tissue Gene Expression: Toward Understanding the Molecular Equivalents of Non-Invasive Tests
- PMID: 35058353
- PMCID: PMC8819994
- DOI: 10.1681/ASN.2021121595
Comparing Plasma Donor-Derived Cell-free DNA to Indication Kidney Biopsy Tissue Gene Expression: Toward Understanding the Molecular Equivalents of Non-Invasive Tests
Keywords: acute allograft rejection; biomarkers; cell free DNA; gene expression.
Comment on
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The Trifecta Study: Comparing Plasma Levels of Donor-derived Cell-Free DNA with the Molecular Phenotype of Kidney Transplant Biopsies.J Am Soc Nephrol. 2022 Feb;33(2):387-400. doi: 10.1681/ASN.2021091191. Epub 2022 Jan 20. J Am Soc Nephrol. 2022. PMID: 35058354 Free PMC article. Clinical Trial.
References
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- Mengel M, Loupy A, Haas M, Roufosse C, Naesens M, Akalin E, et al. : Banff 2019 Meeting Report: Molecular diagnostics in solid organ transplantation-Consensus for the Banff Human Organ Transplant (B-HOT) gene panel and open source multicenter validation. Am J Transplant 20: 2305–2317, 2020 - PMC - PubMed
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- Bloom RD, Bromberg JS, Poggio ED, Bunnapradist S, Langone AJ, Sood P, et al. ; Circulating Donor-Derived Cell-Free DNA in Blood for Diagnosing Active Rejection in Kidney Transplant Recipients (DART) Study Investigators : Cell-free DNA and active rejection in kidney allografts. J Am Soc Nephrol 28: 2221–2232, 2017 - PMC - PubMed
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- Huang E, Sethi S, Peng A, Najjar R, Mirocha J, Haas M, et al. : Early clinical experience using donor-derived cell-free DNA to detect rejection in kidney transplant recipients. Am J Transplant 19: 1663–1670, 2019 - PubMed
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