Reply to: 'Lack of evidence for intergenerational inheritance of immune resistance to infections'

Natalie Katzmarski^#¹, Jorge Domínguez-Andrés^#^{2

3}, Branko Cirovic^#¹, Georgios Renieris⁴, Eleonora Ciarlo⁵, Didier Le Roy⁵, Konstantin Lepikhov⁶, Kathrin Kattler⁶, Gilles Gasparoni⁶, Kristian Händler⁷, Heidi Theis⁷, Marc Beyer^{7

8}, Jos W M van der Meer⁹, Leo A B Joosten^{9

10}, Jörn Walter⁶, Joachim L Schultze^{8

11}, Thierry Roger^#⁵, Evangelos J Giamarellos-Bourboulis^#⁴, Andreas Schlitzer^#¹, Mihai G Netea^#^{9

10

12}

Affiliations

¹ Quantitative Systems Biology, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
² Department of Internal Medicine and Radboud Center for Infectious diseases, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands. jorge.dominguezandres@radboudumc.nl.
³ Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands. jorge.dominguezandres@radboudumc.nl.
⁴ 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
⁵ Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Epalinges, Switzerland.
⁶ Department of Genetics/Epigenetics, Saarland University, Saarbrücken, Germany.
⁷ PRECISE, Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
⁸ Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases, Bonn, Germany.
⁹ Department of Internal Medicine and Radboud Center for Infectious diseases, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
¹⁰ Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
¹¹ Department for Genomics & Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
¹² Department for Immunology & Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

^# Contributed equally.

PMID: 35058615
DOI: 10.1038/s41590-021-01103-z

Comment

Reply to: 'Lack of evidence for intergenerational inheritance of immune resistance to infections'

Natalie Katzmarski et al. Nat Immunol. 2022 Feb.

. 2022 Feb;23(2):208-209.

doi: 10.1038/s41590-021-01103-z. Epub 2022 Jan 20.

Authors

Affiliations

¹ Quantitative Systems Biology, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
² Department of Internal Medicine and Radboud Center for Infectious diseases, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands. jorge.dominguezandres@radboudumc.nl.
³ Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands. jorge.dominguezandres@radboudumc.nl.
⁴ 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
⁵ Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Epalinges, Switzerland.
⁶ Department of Genetics/Epigenetics, Saarland University, Saarbrücken, Germany.
⁷ PRECISE, Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.
⁸ Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases, Bonn, Germany.
⁹ Department of Internal Medicine and Radboud Center for Infectious diseases, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
¹⁰ Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
¹¹ Department for Genomics & Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
¹² Department for Immunology & Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

^# Contributed equally.

PMID: 35058615
DOI: 10.1038/s41590-021-01103-z

No abstract available

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Comment on

Transmission of trained immunity and heterologous resistance to infections across generations.
Katzmarski N, Domínguez-Andrés J, Cirovic B, Renieris G, Ciarlo E, Le Roy D, Lepikhov K, Kattler K, Gasparoni G, Händler K, Theis H, Beyer M, van der Meer JWM, Joosten LAB, Walter J, Schultze JL, Roger T, Giamarellos-Bourboulis EJ, Schlitzer A, Netea MG. Katzmarski N, et al. Nat Immunol. 2021 Nov;22(11):1382-1390. doi: 10.1038/s41590-021-01052-7. Epub 2021 Oct 18. Nat Immunol. 2021. PMID: 34663978
Lack of evidence for intergenerational inheritance of immune resistance to infections.
Kaufmann E, Landekic M, Downey J, Chronopoulos J, Teimouri Nezhad S, Tran K, Vinh DC, Barreiro LB, Divangahi M. Kaufmann E, et al. Nat Immunol. 2022 Feb;23(2):203-207. doi: 10.1038/s41590-021-01102-0. Epub 2022 Jan 20. Nat Immunol. 2022. PMID: 35058614 No abstract available.

References

1. Kaufmann, E. et al. Lack of evidence for intergenerational inheritance of immune resistance to infections. Nat. Immunol. https://doi.org/10.1038/s41590-021-01102-0 (2021).
1. Katzmarski, N. et al. Transmission of trained immunity and heterologous resistance to infections across generations. Nat. Immunol. 22, 1382–1390 (2021). - DOI
1. Luna, E., Bruce, T. J. A., Roberts, M. R., Flors, V. & Ton, J. Next-generation systemic acquired resistance. Plant Physiol. 158, 844–853 (2012). - DOI
1. Mondotte, J. A. et al. Evidence for long-lasting transgenerational antiviral immunity in insects. Cell Rep. 33, 108506 (2020). - DOI
1. Rokade, S. et al. Transient systemic inflammation in adult male mice results in underweight progeny. Am. J. Reprod. Immunol. 86, e13401 (2021). - DOI

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Reply to: 'Lack of evidence for intergenerational inheritance of immune resistance to infections'

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Reply to: 'Lack of evidence for intergenerational inheritance of immune resistance to infections'

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