Walking the LINEs hidden in the dark matter of the genome

Marina Lusic^{1

2}, Musa M Mhlanga^{3

4

5}

Affiliations

¹ Department of Infectious Diseases, Integrative Virology, Heidelberg University Hospital, Heidelberg, Germany.
² German Center for Infection Research (DZIF), Heidelberg, Germany.
³ Epigenomics & Single Cell Biophysics Group, Department of Cell Biology FNWI, Radboud University, Nijmegen, The Netherlands. intrim@mhlangalab.org.
⁴ Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands. intrim@mhlangalab.org.
⁵ Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands. intrim@mhlangalab.org.

Comment

Marina Lusic et al. Nat Genet. 2022 Feb.

. 2022 Feb;54(2):98-99.

doi: 10.1038/s41588-021-01003-w.

Marina Lusic^{1

2}, Musa M Mhlanga^{3

4

5}

¹ Department of Infectious Diseases, Integrative Virology, Heidelberg University Hospital, Heidelberg, Germany.
² German Center for Infection Research (DZIF), Heidelberg, Germany.
³ Epigenomics & Single Cell Biophysics Group, Department of Cell Biology FNWI, Radboud University, Nijmegen, The Netherlands. intrim@mhlangalab.org.
⁴ Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands. intrim@mhlangalab.org.
⁵ Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands. intrim@mhlangalab.org.

No abstract available

Comment on

LINE1 are spliced in non-canonical transcript variants to regulate T cell quiescence and exhaustion.
Marasca F, Sinha S, Vadalà R, Polimeni B, Ranzani V, Paraboschi EM, Burattin FV, Ghilotti M, Crosti M, Negri ML, Campagnoli S, Notarbartolo S, Sartore-Bianchi A, Siena S, Prati D, Montini G, Viale G, Torre O, Harari S, Grifantini R, Soldà G, Biffo S, Abrignani S, Bodega B. Marasca F, et al. Nat Genet. 2022 Feb;54(2):180-193. doi: 10.1038/s41588-021-00989-7. Epub 2022 Jan 17. Nat Genet. 2022. PMID: 35039641

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