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. 1987 Aug 31;73(1-2):145-57.
doi: 10.1007/BF00057445.

Genetics of primate lymphomas in a baboon (Papio hamadryas) colony of Sukhumi, USSR

M H Crawford  1 , E J Devor, D H O'Rourke, L A Yakovleva, A F Voevodin, B A Lapin
Affiliations

Genetics of primate lymphomas in a baboon (Papio hamadryas) colony of Sukhumi, USSR

M H Crawford et al. Genetica. .

Abstract

A lymphoma outbreak occurred at the Sukhumi Center in the Late 1960's, when 12 baboons were inoculated with blood from human leukemia patients. Out of a total of 3219 animals, 218 contracted lymphoma and died. This outbreak appears to be primarily horizontal in transmission. Genetic investigations reveal that: (1) inbreeding does not increase risk of lymphoma; (2) there is a weak association between the PGM2 locus and lymphoma; (3) based upon path analysis, there is evidence of a significant transmissible component (genetic predisposition) passed from the parental to the next generation.

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