Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan 7;8(1):e08720.
doi: 10.1016/j.heliyon.2022.e08720. eCollection 2022 Jan.

Audiological follow-up of children with congenital Zika syndrome

Lilian F Muniz  1 , Rebeka J F Maciel  1 , Danielle S Ramos  1   2 , Kátia M G Albuquerque  3 , Ângela C Leão  3 , Vanessa Van Der Linden  4 , Enny S Paixão  5 , Elizabeth B Brickley  5 , Marli T Cordeiro  6 , Gabriella G S Leitão  1 , Silvio S Caldas  1 , Mariana C Leal  1   3
Affiliations

Audiological follow-up of children with congenital Zika syndrome

Lilian F Muniz et al. Heliyon. .

Abstract

How does the auditory function of children with congenital Zika syndrome present during the first three years of life? To determine the auditory function of children with congenital Zika syndrome during the first three years of life and estimate the frequency and long-term presentation of hearing loss in this syndrome, an auditory assessment with screening and diagnostic tests was conducted. The screening test consisted of measuring the short latency ABR using click stimuli. If the ABR click indicated hearing loss, confirmation was obtained with a frequency-specific ABR (FS-ABR), in which the stimuli were tone bursts at frequencies of 500 and 2000 Hz by bone and air conduction. This case series included 107 children with confirmed congenital Zika syndrome, and the cumulative incidence of sensorineural hearing loss in the first three years of life was 9.3% (10/107). There were no cases of delayed-onset or progressive deficits in hearing. Early presentation of sensorineural hearing loss seems to occur with a higher frequency in children with congenital Zika syndrome than in the general population. Sensorineural hearing loss resulting from congenital Zika virus infection does not appear to present with delayed onset or with progressive deficits.

Keywords: Birth defects; Congenital Zika syndrome; Congenital infection; Hearing loss; Microcephaly; Zika virus.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. de Fatima Vasco Aragao M., van der Linden V., Brainer-Lima A.M., Coeli R.R., Rocha M.A., Sobral da Silva P., Durce Costa Gomes de Carvalho M., van der Linden A., Cesario de Holanda A., Valenca M.M. Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study. BMJ, Br. Med. J. 2016;353 - PMC - PubMed
    1. van der Linden V., Filho E.L., Lins O.G., van der Linden A., Aragão M.d.e.F., Brainer-Lima A.M., Cruz D.D., Rocha M.A., Sobral da Silva P.F., Carvalho M.D., do Amaral F.J., Gomes J.A., Ribeiro de Medeiros I.C., Ventura C.V., Ramos R.C. Congenital Zika syndrome with arthrogryposis: retrospective case series study. BMJ, Br. Med. J. 2016;354 - PMC - PubMed
    1. Ventura C.V., Maia M., Ventura B.V., Linden V.V., Araújo E.B., Ramos R.C., Rocha M.A., Carvalho M.D., Belfort R., Ventura L.O. Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arq. Bras. Oftalmol. 2016;79(1):1–3. - PubMed
    1. Leal M.C., Muniz L.F., Ferreira T.S., Santos C.M., Almeida L.C., Van Der Linden V., Ramos R.C., Rodrigues L.C., Neto S.S. Hearing loss in infants with microcephaly and evidence of congenital Zika virus infection - Brazil, November 2015-May 2016. Morb. Mort. Wkly. Rep. 2016;65(34):917–919. - PubMed
    1. van der Linden V., Pessoa A., Dobyns W., Barkovich A.J., Júnior H.V., Filho E.L., Ribeiro E.M., Leal M.C., Coimbra P.P., Aragão M.F., Verçosa I., Ventura C., Ramos R.C., Cruz D.D., Cordeiro M.T., Mota V.M., Dott M., Hillard C., Moore C.A. Description of 13 infants born during October 2015-January 2016 with congenital Zika virus infection without microcephaly at birth - Brazil. Morb. Mort. Wkly. Rep. 2016;65(47):1343–1348. - PubMed

LinkOut - more resources