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. 2022 May;94(5):2290-2295.
doi: 10.1002/jmv.27613. Epub 2022 Feb 3.

Characteristics of the first 1119 SARS-CoV-2 Omicron variant cases, in Marseille, France, November-December 2021

Linda Houhamdi  1 , Philippe Gautret  1   2 , Van Thuan Hoang  3 , Pierre-Edouard Fournier  1   2 , Philippe Colson  1   4 , Didier Raoult  1   4
Affiliations

Characteristics of the first 1119 SARS-CoV-2 Omicron variant cases, in Marseille, France, November-December 2021

Linda Houhamdi et al. J Med Virol. 2022 May.

Abstract

One thousand one hundred and nineteen cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant cases have been diagnosed at the Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France, between November 28, 2021, and December 31, 2021. Among the 825 patients with known vaccination status, 383 (46.4%) were vaccinated, of whom 91.9% had received at least two doses of the vaccine. Interestingly, 26.3% of cases developed SARS-CoV-2 infection within 21 days following the last dose of vaccine suggesting possible early production of anti-SARS-CoV-2 facilitating antibodies. Twenty-one patients have been hospitalized, one patient required intensive care, and another patient who received a vaccine booster dose died.

Keywords: COVID-19; Delta; Intensive Care Unit; Omicron; SARS-CoV-2; coronavirus; death; hospitalization; infection; vaccination; variant.

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Conflict of interest statement

Didier Raoult has a conflict of interests being a consultant for Hitachi High‐Technologies Corporation, Tokyo, Japan from 2018 to 2020. The remaining authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Dynamic of diagnoses of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection by quantitative polymerase chain reaction (qPCR) and of Omicron and Delta variants between November 28, 2021, and December 31, 2021. Graphic represents the daily distribution of positive cases of SARS‐CoV‐2 infection diagnosed by qPCR (light blue), of cases for which SARS‐CoV‐2 genotype was obtained (dark blue), of infections with the Omicron variant (black), and of infection with the Delta variant (orange) at the Institut Hospitalo‐Universitaire Méditerranée Infection, Marseille, France, between November 28, 2021 and December 31, 2021
Figure 2
Figure 2
Distribution of the numbers of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Omicron infections corresponding to vaccine breakthrough according to time following the last dose of anti‐SARS‐CoV‐2 vaccination. The graphic represents the distribution of diagnoses of SARS‐CoV‐2 infection with the Omicron variant corresponding to vaccine breakthrough according to the number of weeks following anti‐SARS‐CoV‐2 vaccination. The delay to infection was calculated as the difference between the time of the first positive SARS‐CoV‐2 qPCR and that of the vaccine dose (first to fourth dose) last received by the patient
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