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. 2022 Jan 21;23(1):76.
doi: 10.1186/s12891-022-05015-3.

Factors affecting spine-femur discordance in the percentage of young adult mean on dual-energy X-ray absorptiometry in the elderly population: a retrospective study

Shoshi Akiyama  1   2 , Takaaki Tanaka  3   4 , Jun Udaka  4 , Naoya Inagaki  4 , Yoshio Kumagae  3   4 , Masaaki Chazono  3   4 , Tatsuki Matsuoka  4 , Mitsuru Saito  4
Affiliations

Factors affecting spine-femur discordance in the percentage of young adult mean on dual-energy X-ray absorptiometry in the elderly population: a retrospective study

Shoshi Akiyama et al. BMC Musculoskelet Disord. .

Abstract

Background: Several retrospective studies have reported spine-femur discordance in bone mineral density (BMD) values. However, the average age of individuals in these studies was the mid-50s, which is younger than the typical age of individuals requiring treatment for primary osteoporosis. Therefore, we aimed to investigate factors associated with discordance in the percentage of young adult mean (YAM) between the lumbar spine and femoral neck in the elderly population.

Methods: We evaluated 4549 dual-energy X-ray absorptiometry (DXA) measurements obtained from 2161 patients (269 men and 1892 women) between January 2014 and December 2017 at our hospital. For individuals with more than one eligible set of measurements, the first record was used. We investigated each patient's age, sex, body mass index, current smoking status, alcohol consumption, use of steroids, presence of diabetes mellitus, and presence of rheumatoid arthritis.

Results: The mean age of the patients was 76.4 ± 8.9 years. Older age (p < 0.001), male sex (p < 0.001), and diabetes mellitus (p = 0.007) were significantly associated with spine-femur discordance in the percentage of YAM.

Conclusion: The frequency and magnitude of spine-femur discordance in the percentage of YAM from DXA scans increased with age. Notably, more than 77.4% of patients in their 90s had spine-femur discordance > 10% of YAM. Furthermore, the frequency of spine-femur discordance was higher in men and in patients with diabetes mellitus, suggesting that the percentage of YAM at the lumbar spine may not be reliable for diagnosis of osteoporosis in patients with these factors.

Keywords: Bone mineral density; Dual-energy X-ray absorptiometry; Lumbar spine; Osteoporosis; Spine–femur discordance; Young adult mean.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Discordance in the percentage of YAM (percentage of YAM at LS minus percentage of YAM at FN) was categorized according to the following thresholds: <− 10% (group A); ≥ − 10 to < 10% (group B); and ≥ 10% (group C). YAM, young adult mean; LS, lumbar spine; FN, femoral neck
Fig. 2
Fig. 2
The percentage of YAM at LS and FN according to age. Each dot represents one person. The dashed and solid lines approximate the percentage of YAM at LS and FN, respectively. YAM, young adult mean; LS, lumbar spine; FN, femoral neck
Fig. 3
Fig. 3
a An anteroposterior radiograph. b A lateral radiograph. c An axial computed tomography image of the fourth lumbar vertebra reconstructed at the level of the dotted line in the anteroposterior radiograph (a)
See this image and copyright information in PMC

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