Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jan 21;20(1):37.
doi: 10.1186/s12967-022-03245-6.

RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatment

Jiangchun Wu #  1   2 , Yong Wu #  1   2 , Qinhao Guo  1   2 , Simin Wang  1   2 , Xiaohua Wu  3   4
Affiliations
Review

RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatment

Jiangchun Wu et al. J Transl Med. .

Abstract

Ovarian cancer (OC), an important cause of cancer-related death in women worldwide, is one of the most malignant cancers and is characterized by a poor prognosis. RNA-binding proteins (RBPs), a class of endogenous proteins that can bind to mRNAs and modify (or even determine) the amount of protein they can generate, have attracted great attention in the context of various diseases, especially cancers. Compelling studies have suggested that RBPs are aberrantly expressed in different cancer tissues and cell types, including OC tissues and cells. More specifically, RBPs can regulate proliferation, apoptosis, invasion, metastasis, tumorigenesis and chemosensitivity and serve as potential therapeutic targets in OC. Herein, we summarize what is currently known about the biogenesis, molecular functions and potential roles of human RBPs in OC and their prospects for application in the clinical treatment of OC.

Keywords: Ovarian cancer; RNA-binding proteins; Therapeutic targets.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Various mechanisms regulate changes in RBP expression in cancer cells. A Genomic control. B Transcriptional regulation. C Posttranscriptional regulation. D Posttranslational modifications
Fig. 2
Fig. 2
RBPs regulate the functions of transcripts at multiple post-transcriptional levels. A Alternative Splicing. B Alternative Polyadenylation. C RNA Localization. D RNA Stability. E Alternative Splicing
Fig. 3
Fig. 3
RBPs act as oncogenes or tumour suppressors in OC
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics. CA Cancer J Clin. 2021;71(2021):7–33. doi: 10.3322/caac.21654. - DOI - PubMed
    1. Matulonis UA, Sood AK, Fallowfield L, Howitt BE, Sehouli J, Karlan BY. Ovarian cancer. Nat Rev Dis Primers. 2016;2:16061. doi: 10.1038/nrdp.2016.61. - DOI - PMC - PubMed
    1. Blagden S, Abdel Mouti M, Chettle J. Ancient and modern: hints of a core post-transcriptional network driving chemotherapy resistance in ovarian cancer. Wiley Interdiscip Rev RNA. 2018 doi: 10.1002/wrna.1432. - DOI - PMC - PubMed
    1. Narod S. Can advanced-stage ovarian cancer be cured? Nat Rev Clin Oncol. 2016;13:255–261. doi: 10.1038/nrclinonc.2015.224. - DOI - PubMed
    1. Jayson GC, Kohn EC, Kitchener HC, Ledermann JA. Ovarian cancer. Lancet. 2014;384:1376–1388. doi: 10.1016/S0140-6736(13)62146-7. - DOI - PubMed

Publication types