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Comment
. 2022 Jan 20;185(2):230-231.
doi: 10.1016/j.cell.2021.12.042.

One ring doesn't rule them all: Distinct nuclear pore complexes in a single cell

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One ring doesn't rule them all: Distinct nuclear pore complexes in a single cell

Megan R McCarthy et al. Cell. .
Free article

Abstract

Determining the structural plasticity and dynamics of nuclear pore complexes (NPCs) are major challenges. In this issue of Cell, Akey et al. present comprehensive NPC structures from in vitro and in vivo preparations, demonstrating multiple NPC forms in single cells while providing insight into the evolutionary origin of NPC architecture.

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  • Comprehensive structure and functional adaptations of the yeast nuclear pore complex.
    Akey CW, Singh D, Ouch C, Echeverria I, Nudelman I, Varberg JM, Yu Z, Fang F, Shi Y, Wang J, Salzberg D, Song K, Xu C, Gumbart JC, Suslov S, Unruh J, Jaspersen SL, Chait BT, Sali A, Fernandez-Martinez J, Ludtke SJ, Villa E, Rout MP. Akey CW, et al. Cell. 2022 Jan 20;185(2):361-378.e25. doi: 10.1016/j.cell.2021.12.015. Epub 2022 Jan 3. Cell. 2022. PMID: 34982960 Free PMC article.

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