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. 2022 Jun;161(6):1651-1656.
doi: 10.1016/j.chest.2022.01.019. Epub 2022 Jan 19.

Different Cytokine Patterns in BMPR2-Mutation-Positive Patients and Patients With Pulmonary Arterial Hypertension Without Mutations and Their Influence on Survival

Max Schwiening  1 , Emilia M Swietlik  2 , Divya Pandya  3 , Keith Burling  4 , Peter Barker  4 , Oliver Y Feng  5 , Carmen M Treacy  3 , Susana Abreu  1 , S John Wort  6 , Joanna Pepke-Zaba  7 , Stefan Graf  8 , Stefan J Marciniak  9 , Nicholas W Morrell  3 , Elaine Soon  10
Affiliations

Different Cytokine Patterns in BMPR2-Mutation-Positive Patients and Patients With Pulmonary Arterial Hypertension Without Mutations and Their Influence on Survival

Max Schwiening et al. Chest. 2022 Jun.
No abstract available

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Figures

Figure 1
Figure 1
A-D, Graphs show survival curves based on Kaplan-Meier analyses and receiver operating curves. Rows show analyses based on IL-6 (A), TNF-α (B), IL-8 (C), and NT-proBNP (D). The leftmost column shows analyses in BMPR2-mutation-positive patients; the middle column shows analyses in patients with PAH without mutations, and the rightmost column shows the ROC curve that enables a direct comparison in both groups of patients. For A-B, log-rank P values are shown. For C, the P values shown relate to the significance of the AUC compared with the “line of no discrimination.” For ease of reading, the BMPR-2 mutation data are presented in color, and the PAH without mutation data are presented in black. AUC = area under the curve; BMPR2 = bone morphogenetic protein receptor type-2; NT-proBNP = N-terminal pro-B type natriuretic peptide; PAH = pulmonary arterial hypertension; ROC = receiver operating characteristic; TNF = tumor necrosis factor;
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References

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