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Editorial
. 2022 Apr;48(3):e12792.
doi: 10.1111/nan.12792. Epub 2022 Feb 9.

Classification of diseases with accumulation of Tau protein

Gabor G Kovacs  1   2 , Bernardino Ghetti  3 , Michel Goedert  4
Affiliations
Editorial

Classification of diseases with accumulation of Tau protein

Gabor G Kovacs et al. Neuropathol Appl Neurobiol. 2022 Apr.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Neuropathol Appl Neurobiol. 2022 Aug;48(5):e12821. doi: 10.1111/nan.12821. Epub 2022 May 19. Neuropathol Appl Neurobiol. 2022. PMID: 35587750 No abstract available.
No abstract available

Keywords: classification; neurodegeneration; tau; tauopathy.

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Conflict of interest statement

Conflicts of interest

The authors report no conflicts of interest specific to this manuscript.

Figures

Figure 1.
Figure 1.
Classification of diseases with accumulation of Tau protein. *: Myotonic dystrophy, characterized by the preferential aggregation of 0N3R Tau. There have also been reports of the presence of 4R Tau.
See this image and copyright information in PMC

References

    1. Poorkaj P, Bird TD, Wijsman E, Nemens E, Garruto RM, Anderson L, Andreadis A, Wiederholt WC, Raskind M, Schellenberg GD. Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann Neurol 1998; 43: 815–25 - PubMed
    1. Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, Hackett J, Adamson J, Lincoln S, Dickson D, Davies P, Petersen RC, Stevens M, de Graaff E, Wauters E, van Baren J, Hillebrand M, Joosse M, Kwon JM, Nowotny P, Che LK, Norton J, Morris JC, Reed LA, Trojanowski J, Basun H, Lannfelt L, Neystat M, Fahn S, Dark F, Tannenberg T, Dodd PR, Hayward N, Kwok JB, Schofield PR, Andreadis A, Snowden J, Craufurd D, Neary D, Owen F, Oostra BA, Hardy J, Goate A, van Swieten J, Mann D, Lynch T, Heutink P. Association of missense and 5’-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 1998; 393: 702–5 - PubMed
    1. Spillantini MG, Murrell JR, Goedert M, Farlow MR, Klug A, Ghetti B. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc Natl Acad Sci U S A 1998; 95: 7737–41 - PMC - PubMed
    1. Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, Mant R, Newton P, Rooke K, Roques P, Talbot C, Pericak-Vance M, Roses A, Williamson R, Rossor M, Owen M, Hardy J. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease. Nature 1991; 349: 704–6 - PubMed
    1. Murrell J, Farlow M, Ghetti B, Benson MD. A mutation in the amyloid precursor protein associated with hereditary Alzheimer’s disease. Science 1991; 254: 97–9 - PubMed

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