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Review
. 2022 May;123(5):843-851.
doi: 10.1002/jcb.30217. Epub 2022 Jan 22.

The pathophysiology and treatment of musculoskeletal fibrosis

Kelsey Sheets  1 , Juliana Overbey  2 , Andre Ksajikian  2 , Karen Bovid  1 , Keith Kenter  1 , Yong Li  1
Affiliations
Review

The pathophysiology and treatment of musculoskeletal fibrosis

Kelsey Sheets et al. J Cell Biochem. 2022 May.

Abstract

Fibrosis continues to challenge the regeneration and repair of the Orthopaedic tissues in states of injury or disease. The mechanism behind developmental fibrosis has been widely investigated in the last few decades. However, the current efficacy of treatment for existing fibrous scars remains insufficient from both basic research and clinical perspectives. Scarred fibrotic tissue impedes the physical function of affected local tissues and organs and may also be associated with abnormal pain conduction or tissue reinjury. It is necessary to discover the functional treatment for fibrous scars as this pathology is medically demanding to effected patients. The current article will review the mechanisms behind fibrosis formation and the treatment potential in the field of the musculoskeletal system, especially in the pathology and treatment of injured skeletal muscle and the development of osteoarthritis.

Keywords: TGF-ß; extracellular matrix; fibrosis; musculoskeletal; osteoarthritis; stem cells.

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References

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